Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8GJU

Crystal structure of human methylmalonyl-CoA mutase (MMUT) in complex with methylmalonic acidemia type A protein (MMAA), coenzyme A, and GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding
H	0003824	molecular_function	catalytic activity
H	0003924	molecular_function	GTPase activity
H	0004494	molecular_function	methylmalonyl-CoA mutase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006790	biological_process	sulfur compound metabolic process
H	0009791	biological_process	post-embryonic development
H	0016853	molecular_function	isomerase activity
H	0016866	molecular_function	intramolecular transferase activity
H	0019678	biological_process	propionate metabolic process, methylmalonyl pathway
H	0031419	molecular_function	cobalamin binding
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043547	biological_process	positive regulation of GTPase activity
H	0046872	molecular_function	metal ion binding
H	0050667	biological_process	homocysteine metabolic process
H	0072341	molecular_function	modified amino acid binding
H	1901290	biological_process	succinyl-CoA biosynthetic process
J	0003824	molecular_function	catalytic activity
J	0003924	molecular_function	GTPase activity
J	0004494	molecular_function	methylmalonyl-CoA mutase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0006790	biological_process	sulfur compound metabolic process
J	0009791	biological_process	post-embryonic development
J	0016853	molecular_function	isomerase activity
J	0016866	molecular_function	intramolecular transferase activity
J	0019678	biological_process	propionate metabolic process, methylmalonyl pathway
J	0031419	molecular_function	cobalamin binding
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0043547	biological_process	positive regulation of GTPase activity
J	0046872	molecular_function	metal ion binding
J	0050667	biological_process	homocysteine metabolic process
J	0072341	molecular_function	modified amino acid binding
J	1901290	biological_process	succinyl-CoA biosynthetic process
K	0003824	molecular_function	catalytic activity
K	0003924	molecular_function	GTPase activity
K	0004494	molecular_function	methylmalonyl-CoA mutase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0006790	biological_process	sulfur compound metabolic process
K	0009791	biological_process	post-embryonic development
K	0016853	molecular_function	isomerase activity
K	0016866	molecular_function	intramolecular transferase activity
K	0019678	biological_process	propionate metabolic process, methylmalonyl pathway
K	0031419	molecular_function	cobalamin binding
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0043547	biological_process	positive regulation of GTPase activity
K	0046872	molecular_function	metal ion binding
K	0050667	biological_process	homocysteine metabolic process
K	0072341	molecular_function	modified amino acid binding
K	1901290	biological_process	succinyl-CoA biosynthetic process
L	0003824	molecular_function	catalytic activity
L	0003924	molecular_function	GTPase activity
L	0004494	molecular_function	methylmalonyl-CoA mutase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0006790	biological_process	sulfur compound metabolic process
L	0009791	biological_process	post-embryonic development
L	0016853	molecular_function	isomerase activity
L	0016866	molecular_function	intramolecular transferase activity
L	0019678	biological_process	propionate metabolic process, methylmalonyl pathway
L	0031419	molecular_function	cobalamin binding
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0043547	biological_process	positive regulation of GTPase activity
L	0046872	molecular_function	metal ion binding
L	0050667	biological_process	homocysteine metabolic process
L	0072341	molecular_function	modified amino acid binding
L	1901290	biological_process	succinyl-CoA biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00544
Number of Residues	26
Details	METMALONYL_COA_MUTASE Methylmalonyl-CoA mutase signature. RIARNTqiIIqEEsgipKvaDPwGGS

Chain	Residue	Details
J	ARG403-SER428

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:20876572

Chain	Residue	Details
K	TYR96
K	THR106
K	THR216
K	ARG228
K	LYS255
K	HIS265
K	ARG304
L	GLN50
L	TYR96
L	THR106
L	THR216
L	ARG228
L	LYS255
L	HIS265
L	ARG304
H	GLN50
H	TYR96
H	THR106
H	THR216
H	ARG228
H	LYS255
H	HIS265
H	ARG304
K	GLN50
J	GLN50
J	TYR96
J	THR106
J	THR216
J	ARG228
J	LYS255
J	HIS265
J	ARG304

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:20876572

Chain	Residue	Details
J	HIS627
K	HIS627
L	HIS627
H	HIS627

site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P16332

Chain	Residue	Details
J	LYS89
L	LYS212
L	LYS335
L	LYS602
H	LYS89
H	LYS212
H	LYS335
H	LYS602
J	LYS212
J	LYS335
J	LYS602
K	LYS89
K	LYS212
K	LYS335
K	LYS602
L	LYS89

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P16332

Chain	Residue	Details
J	LYS343
J	LYS595
K	LYS343
K	LYS595
L	LYS343
L	LYS595
H	LYS343
H	LYS595

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
J	SER481
K	SER481
L	SER481
H	SER481

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)