8GHD

The structure of h12-LOX in hexameric form bound to inhibitor ML355 and arachidonic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Polyunsaturated fatty acid lipoxygenase ALOX12	polymer	669	76582.7	6	UniProt (P18054) Pfam (PF01477) Pfam (PF00305)	Homo sapiens (human)	Arachidonate (12S)-lipoxygenase,12S-LOX,12S-lipoxygenase,Arachidonate (15S)-lipoxygenase,Linoleate (13S)-lipoxygenase,Lipoxin synthase 12-LO,Platelet-type lipoxygenase 12
2	G, J, M, P, S... (A, B, C, D, E...)	FE (II) ION	non-polymer		55.8	6	Chemie (FE2)
3	H, K, N, Q, T... (A, B, C, D, E...)	N-(1,3-benzothiazol-2-yl)-4-{[(2-hydroxy-3-methoxyphenyl)methyl]amino}benzene-1-sulfonamide	non-polymer		441.5	6	Chemie (ZR5)
4	I, L, O, R, U... (A, B, C, D, E...)	ARACHIDONIC ACID	non-polymer		304.5	6	Chemie (ACD)

Sequence modifications

A, B, C, D, E, F: 2 - 663 (UniProt: P18054)

PDB	External Database	Details
Met -5	-	initiating methionine
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Ser 322	Asn 322	variant

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	459496.2
Non-Polymers*	Number of molecules	18
	Total formula weight	4811.0
All*	Total formula weight	464307.2

*Water molecules are not included.