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8GHD

The structure of h12-LOX in hexameric form bound to inhibitor ML355 and arachidonic acid

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D, E...Polyunsaturated fatty acid lipoxygenase ALOX12polymer66976582.76UniProt (P18054)
Pfam (PF01477)
Pfam (PF00305)
In PDB
Homo sapiens (human)Arachidonate (12S)-lipoxygenase,12S-LOX,12S-lipoxygenase,Arachidonate (15S)-lipoxygenase,Linoleate (13S)-lipoxygenase,Lipoxin synthase 12-LO,Platelet-type lipoxygenase 12
2A, B, C, D, E...FE (II) IONnon-polymer55.86Chemie (FE2)
3A, B, C, D, E...N-(1,3-benzothiazol-2-yl)-4-{[(2-hydroxy-3-methoxyphenyl)methyl]amino}benzene-1-sulfonamidenon-polymer441.56Chemie (ZR5)
4A, B, C, D, E...ARACHIDONIC ACIDnon-polymer304.56Chemie (ACD)
Sequence modifications
A, B, C, D, E, F: 2 - 663 (UniProt: P18054)
PDBExternal DatabaseDetails
Met -5-initiating methionine
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
His 1-expression tag
Ser 322Asn 322variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight459496.2
Non-Polymers*Number of molecules18
Total formula weight4811.0
All*Total formula weight464307.2
*Water molecules are not included.

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PDB entries from 2024-06-12

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