8GHD
The structure of h12-LOX in hexameric form bound to inhibitor ML355 and arachidonic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Polyunsaturated fatty acid lipoxygenase ALOX12 | polymer | 669 | 76582.7 | 6 | UniProt (P18054) Pfam (PF01477) Pfam (PF00305) In PDB | Homo sapiens (human) | Arachidonate (12S)-lipoxygenase,12S-LOX,12S-lipoxygenase,Arachidonate (15S)-lipoxygenase,Linoleate (13S)-lipoxygenase,Lipoxin synthase 12-LO,Platelet-type lipoxygenase 12 |
2 | A, B, C, D, E... | FE (II) ION | non-polymer | 55.8 | 6 | Chemie (FE2) | |||
3 | A, B, C, D, E... | N-(1,3-benzothiazol-2-yl)-4-{[(2-hydroxy-3-methoxyphenyl)methyl]amino}benzene-1-sulfonamide | non-polymer | 441.5 | 6 | Chemie (ZR5) | |||
4 | A, B, C, D, E... | ARACHIDONIC ACID | non-polymer | 304.5 | 6 | Chemie (ACD) |
Sequence modifications
A, B, C, D, E, F: 2 - 663 (UniProt: P18054)
PDB | External Database | Details |
---|---|---|
Met -5 | - | initiating methionine |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
Ser 322 | Asn 322 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 459496.2 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 4811.0 | |
All* | Total formula weight | 464307.2 |