8GAE
Hsp90 provides platform for CRaf dephosphorylation by PP5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heat shock protein HSP 90-beta | polymer | 727 | 83595.5 | 2 | UniProt (P08238) Pfam (PF13589) Pfam (PF00183) | Homo sapiens (human) | HSP 90,Heat shock 84 kDa,HSP 84,HSP84 |
| 2 | C (C) | Hsp90 co-chaperone Cdc37 | polymer | 384 | 45352.2 | 1 | UniProt (Q16543) Pfam (PF03234) Pfam (PF08565) Pfam (PF08564) | Homo sapiens (human) | Hsp90 chaperone protein kinase-targeting subunit,p50Cdc37 |
| 3 | D (D) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 207 | 23841.6 | 1 | UniProt (P04049) Pfam (PF00069) | Homo sapiens (human) | Proto-oncogene c-RAF,cRaf,Raf-1 |
| 4 | E (E) | Serine/threonine-protein phosphatase 5 | polymer | 503 | 57184.7 | 1 | UniProt (P53041) Pfam (PF00515) Pfam (PF08321) Pfam (PF00149) | Homo sapiens (human) | PP5,Protein phosphatase T,PP-T,PPT |
| 5 | F, I (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 6 | G, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | H (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 8 | K (B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 9 | L, M (E) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) |
Sequence modifications
A, B: 1 - 724 (UniProt: P08238)
C: 1 - 378 (UniProt: Q16543)
E: 1 - 499 (UniProt: P53041)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 379 | - | expression tag |
| Glu 380 | - | expression tag |
| Val 381 | - | expression tag |
| Leu 382 | - | expression tag |
| Phe 383 | - | expression tag |
| Gln 384 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 304 | His 304 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 293569.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1171.1 | |
| All* | Total formula weight | 294740.6 |
