8FYH

G4 RNA-mediated PRC2 dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, G (B, H)	Polycomb protein SUZ12	polymer	739	83181.9	2	UniProt (Q15022) Pfam (PF09733)	Homo sapiens (human)	Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
2	B, H (C, I)	Polycomb protein EED	polymer	441	50267.7	2	UniProt (O75530) Pfam (PF00400)	Homo sapiens (human)	hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1
3	C, I (D, J)	Histone-binding protein RBBP4	polymer	425	47709.5	2	UniProt (Q09028) Pfam (PF12265) Pfam (PF00400)	Homo sapiens (human)	Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48
4	D, J (A, G)	Histone-lysine N-methyltransferase EZH2	polymer	751	86149.1	2	UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856)	Homo sapiens (human)	ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6
5	E, K (E, K)	protein Jumonji isoform X3	polymer	1238	138406.2	2	UniProt (A0A6I9KXB3) Pfam (PF02375) Pfam (PF01388) Pfam (PF02373) Pfam (PF02928)	Homo sapiens (human)
6	F, L (F, L)	Zinc finger protein AEBP2	polymer	517	54535.5	2	UniProt (Q6ZN18)	Homo sapiens (human)	Adipocyte enhancer-binding protein 2,AE-binding protein 2
7	M (M)	G4 RNA	polymer	24	7955.8	1		Homo sapiens
8	AA, N, O, P, Q... (G, A)	ZINC ION	non-polymer		65.4	14	Chemie (ZN)

Contents of the asymmetric unit

Polymers	Number of chains	13
	Total formula weight	928455.6
Non-Polymers*	Number of molecules	14
	Total formula weight	915.7
All*	Total formula weight	929371.4

*Water molecules are not included.