Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8FYH

G4 RNA-mediated PRC2 dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006338	biological_process	chromatin remodeling
A	0042054	molecular_function	histone methyltransferase activity
A	0046976	molecular_function	histone H3K27 methyltransferase activity
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
B	0001222	molecular_function	transcription corepressor binding
B	0001739	cellular_component	sex chromatin
B	0003682	molecular_function	chromatin binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005677	cellular_component	chromatin silencing complex
B	0005730	cellular_component	nucleolus
B	0006325	biological_process	chromatin organization
B	0008047	molecular_function	enzyme activator activity
B	0008283	biological_process	cell population proliferation
B	0008284	biological_process	positive regulation of cell population proliferation
B	0016586	cellular_component	RSC-type complex
B	0016604	cellular_component	nuclear body
B	0031490	molecular_function	chromatin DNA binding
B	0032993	cellular_component	protein-DNA complex
B	0035064	molecular_function	methylated histone binding
B	0035098	cellular_component	ESC/E(Z) complex
B	0043565	molecular_function	sequence-specific DNA binding
B	0045596	biological_process	negative regulation of cell differentiation
B	0046872	molecular_function	metal ion binding
B	0048709	biological_process	oligodendrocyte differentiation
B	0060816	biological_process	random inactivation of X chromosome
B	0106222	molecular_function	lncRNA binding
B	0140718	biological_process	facultative heterochromatin formation
B	1990841	molecular_function	promoter-specific chromatin binding
B	1990904	cellular_component	ribonucleoprotein complex
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0001222	molecular_function	transcription corepressor binding
C	0003682	molecular_function	chromatin binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005829	cellular_component	cytosol
C	0006325	biological_process	chromatin organization
C	0008047	molecular_function	enzyme activator activity
C	0021510	biological_process	spinal cord development
C	0031491	molecular_function	nucleosome binding
C	0031507	biological_process	heterochromatin formation
C	0035098	cellular_component	ESC/E(Z) complex
C	0042802	molecular_function	identical protein binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
D	0000118	cellular_component	histone deacetylase complex
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000781	cellular_component	chromosome, telomeric region
D	0000785	cellular_component	chromatin
D	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0006335	biological_process	DNA replication-dependent chromatin assembly
D	0006338	biological_process	chromatin remodeling
D	0006355	biological_process	regulation of DNA-templated transcription
D	0007420	biological_process	brain development
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0008285	biological_process	negative regulation of cell population proliferation
D	0016581	cellular_component	NuRD complex
D	0016589	cellular_component	NURF complex
D	0030336	biological_process	negative regulation of cell migration
D	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
D	0031492	molecular_function	nucleosomal DNA binding
D	0032991	cellular_component	protein-containing complex
D	0033186	cellular_component	CAF-1 complex
D	0035098	cellular_component	ESC/E(Z) complex
D	0042393	molecular_function	histone binding
D	0042659	biological_process	regulation of cell fate specification
D	0042826	molecular_function	histone deacetylase binding
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0070822	cellular_component	Sin3-type complex
D	1902455	biological_process	negative regulation of stem cell population maintenance
D	1902459	biological_process	positive regulation of stem cell population maintenance
D	1904949	cellular_component	ATPase complex
D	2000736	biological_process	regulation of stem cell differentiation
E	0000785	cellular_component	chromatin
E	0003677	molecular_function	DNA binding
E	0005634	cellular_component	nucleus
E	0006325	biological_process	chromatin organization
E	0006338	biological_process	chromatin remodeling
E	0010468	biological_process	regulation of gene expression
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000785	cellular_component	chromatin
F	0003677	molecular_function	DNA binding
F	0003712	molecular_function	transcription coregulator activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0006325	biological_process	chromatin organization
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0035098	cellular_component	ESC/E(Z) complex
F	0046872	molecular_function	metal ion binding
G	0006338	biological_process	chromatin remodeling
G	0042054	molecular_function	histone methyltransferase activity
G	0046976	molecular_function	histone H3K27 methyltransferase activity
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
H	0001222	molecular_function	transcription corepressor binding
H	0001739	cellular_component	sex chromatin
H	0003682	molecular_function	chromatin binding
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005677	cellular_component	chromatin silencing complex
H	0005730	cellular_component	nucleolus
H	0006325	biological_process	chromatin organization
H	0008047	molecular_function	enzyme activator activity
H	0008283	biological_process	cell population proliferation
H	0008284	biological_process	positive regulation of cell population proliferation
H	0016586	cellular_component	RSC-type complex
H	0016604	cellular_component	nuclear body
H	0031490	molecular_function	chromatin DNA binding
H	0032993	cellular_component	protein-DNA complex
H	0035064	molecular_function	methylated histone binding
H	0035098	cellular_component	ESC/E(Z) complex
H	0043565	molecular_function	sequence-specific DNA binding
H	0045596	biological_process	negative regulation of cell differentiation
H	0046872	molecular_function	metal ion binding
H	0048709	biological_process	oligodendrocyte differentiation
H	0060816	biological_process	random inactivation of X chromosome
H	0106222	molecular_function	lncRNA binding
H	0140718	biological_process	facultative heterochromatin formation
H	1990841	molecular_function	promoter-specific chromatin binding
H	1990904	cellular_component	ribonucleoprotein complex
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0001222	molecular_function	transcription corepressor binding
I	0003682	molecular_function	chromatin binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005829	cellular_component	cytosol
I	0006325	biological_process	chromatin organization
I	0008047	molecular_function	enzyme activator activity
I	0021510	biological_process	spinal cord development
I	0031491	molecular_function	nucleosome binding
I	0031507	biological_process	heterochromatin formation
I	0035098	cellular_component	ESC/E(Z) complex
I	0042802	molecular_function	identical protein binding
I	0045892	biological_process	negative regulation of DNA-templated transcription
J	0000118	cellular_component	histone deacetylase complex
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000781	cellular_component	chromosome, telomeric region
J	0000785	cellular_component	chromatin
J	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005694	cellular_component	chromosome
J	0005829	cellular_component	cytosol
J	0006260	biological_process	DNA replication
J	0006325	biological_process	chromatin organization
J	0006334	biological_process	nucleosome assembly
J	0006335	biological_process	DNA replication-dependent chromatin assembly
J	0006338	biological_process	chromatin remodeling
J	0006355	biological_process	regulation of DNA-templated transcription
J	0007420	biological_process	brain development
J	0008094	molecular_function	ATP-dependent activity, acting on DNA
J	0008285	biological_process	negative regulation of cell population proliferation
J	0016581	cellular_component	NuRD complex
J	0016589	cellular_component	NURF complex
J	0030336	biological_process	negative regulation of cell migration
J	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
J	0031492	molecular_function	nucleosomal DNA binding
J	0032991	cellular_component	protein-containing complex
J	0033186	cellular_component	CAF-1 complex
J	0035098	cellular_component	ESC/E(Z) complex
J	0042393	molecular_function	histone binding
J	0042659	biological_process	regulation of cell fate specification
J	0042826	molecular_function	histone deacetylase binding
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0070822	cellular_component	Sin3-type complex
J	1902455	biological_process	negative regulation of stem cell population maintenance
J	1902459	biological_process	positive regulation of stem cell population maintenance
J	1904949	cellular_component	ATPase complex
J	2000736	biological_process	regulation of stem cell differentiation
K	0000785	cellular_component	chromatin
K	0003677	molecular_function	DNA binding
K	0005634	cellular_component	nucleus
K	0006325	biological_process	chromatin organization
K	0006338	biological_process	chromatin remodeling
K	0010468	biological_process	regulation of gene expression
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0000785	cellular_component	chromatin
L	0003677	molecular_function	DNA binding
L	0003712	molecular_function	transcription coregulator activity
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0006325	biological_process	chromatin organization
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0035098	cellular_component	ESC/E(Z) complex
L	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	24
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CcwdqCqacFnsspdladHirsi.H

Chain	Residue	Details
F	CYS55-HIS78
F	CYS122-HIS144
B	CYS450-HIS471

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI

Chain	Residue	Details
D	LEU193-ILE207
D	LEU289-LEU303
D	LEU333-LEU347
C	LEU206-ILE220

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	ZN_FING: C2H2-type 1 => ECO:0000255\|PROSITE-ProRule:PRU00042

Chain	Residue	Details
F	TYR53-HIS78
L	TYR53-HIS78

site_id	SWS_FT_FI2
Number of Residues	44
Details	ZN_FING: C2H2-type 2; degenerate => ECO:0000255\|PROSITE-ProRule:PRU00042

Chain	Residue	Details
F	LYS92-HIS114
L	LYS92-HIS114
G	SER76
G	SER368

site_id	SWS_FT_FI3
Number of Residues	48
Details	ZN_FING: C2H2-type 3 => ECO:0000255\|PROSITE-ProRule:PRU00042

Chain	Residue	Details
F	PHE120-HIS144
L	PHE120-HIS144
B	SER726
H	SER20
H	SER541
H	SER726

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
F	ALA-206
L	ALA-206
C	LYS268
C	LYS284
I	LYS66
I	LYS197
I	LYS268
I	LYS284

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
F	SER-190
F	SER-184
L	SER-190
L	SER-184

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
F	SER-67
L	SER-67
H	LYS72
H	LYS73

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
F	SER-2
L	SER-2
B	LYS390
J	LYS160
H	LYS223
H	LYS390

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
F	SER2
F	SER3
L	SER2
L	SER3

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692

Chain	Residue	Details
F	SER182
L	SER182
G	LYS639

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)