8FX4

GC-C-Hsp90-Cdc37 regulatory complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Heat shock protein HSP 90-beta	polymer	724	83387.3	2	UniProt (A0A8C2MUK8)	Cricetulus griseus (Chinese hamster)
2	C (C)	Hsp90 co-chaperone Cdc37	polymer	379	44549.4	1	UniProt (G3H6C5) Pfam (PF03234) Pfam (PF08565) Pfam (PF08564)	Cricetulus griseus (Chinese hamster)
3	D (D)	Guanylyl cyclase C	polymer	741	85974.7	1	UniProt (P25092) Pfam (PF07714) Pfam (PF00211)	Homo sapiens (human)	GC-C,Heat-stable enterotoxin receptor,STA receptor,hSTAR,Intestinal guanylate cyclase
4	E, F (A, B)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)

Sequence modifications

C: 1 - 379 (UniProt: G3H6C5)

PDB	External Database	Details
Glu 48	Asp 48	conflict

D: 396 - 1050 (UniProt: P25092)

PDB	External Database	Details
Asp 344	-	expression tag
Tyr 345	-	expression tag
Lys 346	-	expression tag
Asp 347	-	expression tag
Asp 348	-	expression tag
Asp 349	-	expression tag
Asp 350	-	expression tag
Lys 351	-	expression tag
Gly 352	-	expression tag
Ser 353	-	expression tag
Leu 354	-	expression tag
Glu 355	-	expression tag
Val 356	-	expression tag
Leu 357	-	expression tag
Phe 358	-	expression tag
Gln 359	-	expression tag
Gly 360	-	expression tag
Pro 361	-	expression tag
Gly 362	-	expression tag
Arg 363	-	expression tag
Met 364	-	expression tag
Lys 365	-	expression tag
Gln 366	-	expression tag
Leu 367	-	expression tag
Glu 368	-	expression tag
Asp 369	-	expression tag
Lys 370	-	expression tag
Val 371	-	expression tag
Glu 372	-	expression tag
Glu 373	-	expression tag
Leu 374	-	expression tag
Leu 375	-	expression tag
Ser 376	-	expression tag
Lys 377	-	expression tag
Asn 378	-	expression tag
Tyr 379	-	expression tag
His 380	-	expression tag
Leu 381	-	expression tag
Glu 382	-	expression tag
Asn 383	-	expression tag
Glu 384	-	expression tag
Val 385	-	expression tag
Ala 386	-	expression tag
Arg 387	-	expression tag
Leu 388	-	expression tag
Lys 389	-	expression tag
Lys 390	-	expression tag
Leu 391	-	expression tag
Val 392	-	expression tag
Gly 393	-	expression tag
Glu 394	-	expression tag
Arg 395	-	expression tag
Ala 1051	-	expression tag
Ala 1052	-	expression tag
Ala 1053	-	expression tag
Leu 1054	-	expression tag
Glu 1055	-	expression tag
Val 1056	-	expression tag
Leu 1057	-	expression tag
Phe 1058	-	expression tag
Gln 1059	-	expression tag
Gly 1060	-	expression tag
Pro 1061	-	expression tag
Gly 1062	-	expression tag
Ala 1063	-	expression tag
Ala 1064	-	expression tag
Glu 1065	-	expression tag
Asp 1066	-	expression tag
Gln 1067	-	expression tag
Val 1068	-	expression tag
Asp 1069	-	expression tag
Pro 1070	-	expression tag
Arg 1071	-	expression tag
Leu 1072	-	expression tag
Ile 1073	-	expression tag
Asp 1074	-	expression tag
Gly 1075	-	expression tag
Lys 1076	-	expression tag
His 1077	-	expression tag
His 1078	-	expression tag
His 1079	-	expression tag
His 1080	-	expression tag
His 1081	-	expression tag
His 1082	-	expression tag
His 1083	-	expression tag
His 1084	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	297298.7
Non-Polymers*	Number of molecules	2
	Total formula weight	1014.4
All*	Total formula weight	298313.0

*Water molecules are not included.