8FW5
Chimeric HsGATOR1-SpGtr-SpLam complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GATOR complex protein DEPDC5 | polymer | 1603 | 181325.8 | 1 | UniProt (O75140) Pfam (PF23013) Pfam (PF12257) Pfam (PF00610) Pfam (PF19418) In PDB | Homo sapiens (human) | DEP domain-containing protein 5 |
2 | B | GATOR complex protein NPRL2 | polymer | 401 | 45799.5 | 1 | UniProt (Q8WTW4) Pfam (PF06218) In PDB | Homo sapiens (human) | Gene 21 protein,G21 protein,Nitrogen permease regulator 2-like protein,NPR2-like protein,Tumor suppressor candidate 4 |
3 | C | GATOR complex protein NPRL3 | polymer | 590 | 65769.0 | 1 | UniProt (Q12980) Pfam (PF03666) In PDB | Homo sapiens (human) | -14 gene protein,Alpha-globin regulatory element-containing gene protein,Nitrogen permease regulator 3-like protein,Protein CGTHBA |
4 | D | GTP-binding protein Gtr1 | polymer | 321 | 36500.4 | 1 | Pfam (PF04670) UniProt (by SIFTS) (O74824) In PDB | Escherichia coli | |
5 | E | GTP-binding protein Gtr2 | polymer | 314 | 35547.6 | 1 | Pfam (PF04670) UniProt (by SIFTS) (O74544) In PDB | Escherichia coli | |
6 | F | Schizosaccharomyces pombe LAM1, Human LAMTOR1 ortholog | polymer | 377 | 43686.8 | 1 | Pfam (PF02798) Pfam (PF14497) UniProt (by SIFTS) (P08515) UniProt (by SIFTS) (C6Y4C6) In PDB | Escherichia coli | |
7 | G | Schizosaccharomyces pombe LAM2, Human LAMTOR2 ortholog | polymer | 181 | 19830.9 | 1 | UniProt (by SIFTS) (Q9Y7J2) In PDB | Escherichia coli | |
8 | H | Schizosaccharomyces pombe LAM3, Human LAMTOR3 ortholog | polymer | 117 | 12707.5 | 1 | UniProt (by SIFTS) (G2TRJ4) In PDB | Escherichia coli | |
9 | I | Schizosaccharomyces pombe LAM4, Human LAMTOR5 ortholog | polymer | 81 | 8984.2 | 1 | UniProt (by SIFTS) (C6Y4A8) In PDB | Escherichia coli | |
10 | D, E | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
11 | D | ALUMINUM FLUORIDE | non-polymer | 84.0 | 1 | Chemie (AF3) | |||
12 | D | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: 1 - 1603 (UniProt: O75140)
B: 1 - 380 (UniProt: Q8WTW4)
C: 1 - 569 (UniProt: Q12980)
PDB | External Database | Details |
---|---|---|
Pro 674 | Arg 674 | conflict |
Ala 775 | Tyr 775 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -20 | - | expression tag |
Gly -19 | - | expression tag |
Tyr -18 | - | expression tag |
Pro -17 | - | expression tag |
Tyr -16 | - | expression tag |
Asp -15 | - | expression tag |
Val -14 | - | expression tag |
Pro -13 | - | expression tag |
Asp -12 | - | expression tag |
Tyr -11 | - | expression tag |
Ala -10 | - | expression tag |
Asp -9 | - | expression tag |
Leu -8 | - | expression tag |
Asn -7 | - | expression tag |
Gly -6 | - | expression tag |
Gly -5 | - | expression tag |
Gly -4 | - | expression tag |
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Thr 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -20 | - | expression tag |
Gly -19 | - | expression tag |
Tyr -18 | - | expression tag |
Pro -17 | - | expression tag |
Tyr -16 | - | expression tag |
Asp -15 | - | expression tag |
Val -14 | - | expression tag |
Pro -13 | - | expression tag |
Asp -12 | - | expression tag |
Tyr -11 | - | expression tag |
Ala -10 | - | expression tag |
Asp -9 | - | expression tag |
Leu -8 | - | expression tag |
Asn -7 | - | expression tag |
Gly -6 | - | expression tag |
Gly -5 | - | expression tag |
Gly -4 | - | expression tag |
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 9 |
Total formula weight | 450151.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 994.7 | |
All* | Total formula weight | 451146.5 |