8FW5
Chimeric HsGATOR1-SpGtr-SpLam complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GATOR complex protein DEPDC5 | polymer | 1603 | 181325.8 | 1 | UniProt (O75140) Pfam (PF23013) Pfam (PF12257) Pfam (PF00610) Pfam (PF19418) | Homo sapiens (human) | DEP domain-containing protein 5 |
| 2 | B (B) | GATOR complex protein NPRL2 | polymer | 401 | 45799.5 | 1 | UniProt (Q8WTW4) Pfam (PF06218) | Homo sapiens (human) | Gene 21 protein,G21 protein,Nitrogen permease regulator 2-like protein,NPR2-like protein,Tumor suppressor candidate 4 |
| 3 | C (C) | GATOR complex protein NPRL3 | polymer | 590 | 65769.0 | 1 | UniProt (Q12980) Pfam (PF03666) Pfam (PF24064) | Homo sapiens (human) | -14 gene protein,Alpha-globin regulatory element-containing gene protein,Nitrogen permease regulator 3-like protein,Protein CGTHBA |
| 4 | D (D) | GTP-binding protein Gtr1 | polymer | 321 | 36500.4 | 1 | Pfam (PF04670) UniProt (by SIFTS) (O74824) | Escherichia coli | |
| 5 | E (E) | GTP-binding protein Gtr2 | polymer | 314 | 35547.6 | 1 | Pfam (PF04670) UniProt (by SIFTS) (O74544) | Escherichia coli | |
| 6 | F (F) | Schizosaccharomyces pombe LAM1, Human LAMTOR1 ortholog | polymer | 377 | 43686.8 | 1 | UniProt (by SIFTS) (P08515) UniProt (by SIFTS) (C6Y4C6) | Escherichia coli | |
| 7 | G (G) | Schizosaccharomyces pombe LAM2, Human LAMTOR2 ortholog | polymer | 181 | 19830.9 | 1 | UniProt (by SIFTS) (Q9Y7J2) | Escherichia coli | |
| 8 | H (H) | Schizosaccharomyces pombe LAM3, Human LAMTOR3 ortholog | polymer | 117 | 12707.5 | 1 | UniProt (by SIFTS) (G2TRJ4) | Escherichia coli | |
| 9 | I (I) | Schizosaccharomyces pombe LAM4, Human LAMTOR5 ortholog | polymer | 81 | 8984.2 | 1 | UniProt (by SIFTS) (C6Y4A8) | Escherichia coli | |
| 10 | J, M (D, E) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 11 | K (D) | ALUMINUM FLUORIDE | non-polymer | 84.0 | 1 | Chemie (AF3) | |||
| 12 | L (D) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: 1 - 1603 (UniProt: O75140)
B: 1 - 380 (UniProt: Q8WTW4)
C: 1 - 569 (UniProt: Q12980)
| PDB | External Database | Details |
|---|---|---|
| Pro 674 | Arg 674 | conflict |
| Ala 775 | Tyr 775 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Tyr -18 | - | expression tag |
| Pro -17 | - | expression tag |
| Tyr -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Val -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Tyr -11 | - | expression tag |
| Ala -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Thr 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Tyr -18 | - | expression tag |
| Pro -17 | - | expression tag |
| Tyr -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Val -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Tyr -11 | - | expression tag |
| Ala -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 450151.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 994.7 | |
| All* | Total formula weight | 451146.5 |
