8FW5

Chimeric HsGATOR1-SpGtr-SpLam complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005096	molecular_function	GTPase activator activity
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005829	cellular_component	cytosol
A	0010508	biological_process	positive regulation of autophagy
A	0031267	molecular_function	small GTPase binding
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
A	0034198	biological_process	cellular response to amino acid starvation
A	0035556	biological_process	intracellular signal transduction
A	0044877	molecular_function	protein-containing complex binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1990130	cellular_component	GATOR1 complex
B	0005096	molecular_function	GTPase activator activity
B	0005515	molecular_function	protein binding
B	0005765	cellular_component	lysosomal membrane
B	0005774	cellular_component	vacuolar membrane
B	0033673	biological_process	negative regulation of kinase activity
B	0034198	biological_process	cellular response to amino acid starvation
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1990130	cellular_component	GATOR1 complex
C	0005096	molecular_function	GTPase activator activity
C	0005515	molecular_function	protein binding
C	0005765	cellular_component	lysosomal membrane
C	0010508	biological_process	positive regulation of autophagy
C	0032007	biological_process	negative regulation of TOR signaling
C	0034198	biological_process	cellular response to amino acid starvation
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1990130	cellular_component	GATOR1 complex
D	0000166	molecular_function	nucleotide binding
D	0000329	cellular_component	fungal-type vacuole membrane
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005774	cellular_component	vacuolar membrane
D	0005829	cellular_component	cytosol
D	0009267	biological_process	cellular response to starvation
D	0010507	biological_process	negative regulation of autophagy
D	0016787	molecular_function	hydrolase activity
D	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0110045	biological_process	negative regulation of cell cycle switching, mitotic to meiotic cell cycle
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling
D	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
E	0000166	molecular_function	nucleotide binding
E	0000329	cellular_component	fungal-type vacuole membrane
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005774	cellular_component	vacuolar membrane
E	0005829	cellular_component	cytosol
E	0009267	biological_process	cellular response to starvation
E	0010507	biological_process	negative regulation of autophagy
E	0016787	molecular_function	hydrolase activity
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0110045	biological_process	negative regulation of cell cycle switching, mitotic to meiotic cell cycle
E	1904263	biological_process	positive regulation of TORC1 signaling
E	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
F	0000329	cellular_component	fungal-type vacuole membrane
F	0003674	molecular_function	molecular_function
F	0004364	molecular_function	glutathione transferase activity
F	0006749	biological_process	glutathione metabolic process
F	0016740	molecular_function	transferase activity
F	0038202	biological_process	TORC1 signaling
F	0071230	biological_process	cellular response to amino acid stimulus
F	0071986	cellular_component	Ragulator complex
F	1903432	biological_process	regulation of TORC1 signaling
G	0000329	cellular_component	fungal-type vacuole membrane
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0032008	biological_process	positive regulation of TOR signaling
G	0038202	biological_process	TORC1 signaling
G	0043495	molecular_function	protein-membrane adaptor activity
G	0060090	molecular_function	molecular adaptor activity
G	0071230	biological_process	cellular response to amino acid stimulus
G	0071986	cellular_component	Ragulator complex
G	1903432	biological_process	regulation of TORC1 signaling
G	1904262	biological_process	negative regulation of TORC1 signaling
H	0000329	cellular_component	fungal-type vacuole membrane
H	0003674	molecular_function	molecular_function
H	0038202	biological_process	TORC1 signaling
H	0071230	biological_process	cellular response to amino acid stimulus
H	0071986	cellular_component	Ragulator complex
H	1903432	biological_process	regulation of TORC1 signaling
I	0000329	cellular_component	fungal-type vacuole membrane
I	0003674	molecular_function	molecular_function
I	0038202	biological_process	TORC1 signaling
I	0071230	biological_process	cellular response to amino acid stimulus
I	0071986	cellular_component	Ragulator complex
I	1903432	biological_process	regulation of TORC1 signaling

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Arginine finger","evidences":[{"source":"PubMed","id":"30651352","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Asymmetric dimethylarginine","evidences":[{"source":"PubMed","id":"38006878","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36528027","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q00582","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P53290","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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