8FCA
Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily V member 4 | polymer | 901 | 102057.8 | 4 | UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520) | Homo sapiens (human) | TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC |
| 2 | E, G, J, L (A, B, C, D) | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate | non-polymer | 672.9 | 4 | Chemie (XS9) PubChem (16219901) PubChem (16219908) PubChem (24058664) PubChem (49864468) PubChem (71308620) PubChem (71308764) PubChem (452544) PubChem (452543) PubChem (537379) PubChem (146158450) PubChem (172432062) PubChem (172897872) | |||
| 3 | F, H, I, K (A, B, C, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (45489984) PubChem (363416) PubChem (60078761) PubChem (500055) PubChem (73440805) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (99567469) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (13301926) PubChem (13301927) PubChem (124914595) PubChem (124914596) PubChem (155804219) PubChem (169132514) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) |
Sequence modifications
A, B, C, D: 1 - 871 (UniProt: Q9HBA0)
| PDB | External Database | Details |
|---|---|---|
| Glu 872 | - | expression tag |
| Asn 873 | - | expression tag |
| Ser 874 | - | expression tag |
| Leu 875 | - | expression tag |
| Glu 876 | - | expression tag |
| Val 877 | - | expression tag |
| Leu 878 | - | expression tag |
| Phe 879 | - | expression tag |
| Gln 880 | - | expression tag |
| Gly 881 | - | expression tag |
| Pro 882 | - | expression tag |
| Asp 883 | - | expression tag |
| Tyr 884 | - | expression tag |
| Lys 885 | - | expression tag |
| Asp 886 | - | expression tag |
| Asp 887 | - | expression tag |
| Asp 888 | - | expression tag |
| Asp 889 | - | expression tag |
| Lys 890 | - | expression tag |
| Ala 891 | - | expression tag |
| His 892 | - | expression tag |
| His 893 | - | expression tag |
| His 894 | - | expression tag |
| His 895 | - | expression tag |
| His 896 | - | expression tag |
| His 897 | - | expression tag |
| His 898 | - | expression tag |
| His 899 | - | expression tag |
| His 900 | - | expression tag |
| His 901 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 408231.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4638.6 | |
| All* | Total formula weight | 412869.8 |
