8FCA

Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Transient receptor potential cation channel subfamily V member 4	polymer	901	102057.8	4	UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520) In PDB	Homo sapiens (human)	TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC
2	A, B, C, D	(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate	non-polymer		672.9	4	Chemie (XS9)
3	A, B, C, D	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	4	Chemie (Y01)

Sequence modifications

A, B, C, D: 1 - 871 (UniProt: Q9HBA0)

PDB	External Database	Details
Glu 872	-	expression tag
Asn 873	-	expression tag
Ser 874	-	expression tag
Leu 875	-	expression tag
Glu 876	-	expression tag
Val 877	-	expression tag
Leu 878	-	expression tag
Phe 879	-	expression tag
Gln 880	-	expression tag
Gly 881	-	expression tag
Pro 882	-	expression tag
Asp 883	-	expression tag
Tyr 884	-	expression tag
Lys 885	-	expression tag
Asp 886	-	expression tag
Asp 887	-	expression tag
Asp 888	-	expression tag
Asp 889	-	expression tag
Lys 890	-	expression tag
Ala 891	-	expression tag
His 892	-	expression tag
His 893	-	expression tag
His 894	-	expression tag
His 895	-	expression tag
His 896	-	expression tag
His 897	-	expression tag
His 898	-	expression tag
His 899	-	expression tag
His 900	-	expression tag
His 901	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	408231.2
Non-Polymers*	Number of molecules	8
	Total formula weight	4638.6
All*	Total formula weight	412869.8

*Water molecules are not included.