8EOK
Structure of the C3bB proconvertase in complex with lufaxin and factor Xa
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | Complement C3 beta chain | polymer | 645 | 71393.3 | 1 | UniProt (P01024) Pfam (PF17789) Pfam (PF07703) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) | Homo sapiens (human) | |
| 2 | B (H) | Complement C3b alpha' chain | polymer | 915 | 104073.2 | 1 | UniProt (P01024) Pfam (PF00207) Pfam (PF21406) Pfam (PF07678) Pfam (PF21308) Pfam (PF07677) Pfam (PF01759) | Homo sapiens (human) | |
| 3 | C (D) | Complement factor B | polymer | 763 | 85510.6 | 1 | UniProt (P00751) Pfam (PF00084) Pfam (PF00092) Pfam (PF00089) | Homo sapiens (human) | C3/C5 convertase,Glycine-rich beta glycoprotein,GBG,PBF2,Properdin factor B |
| 4 | D (A) | Lufaxin | polymer | 284 | 33354.6 | 1 | UniProt (Q5WPU8) | Lutzomyia longipalpis | 32.4 kDa salivary protein,Lutzomyia longipalpis FXa inhibitor |
| 5 | E (L) | Factor X light chain | polymer | 134 | 15210.8 | 1 | UniProt (P00742) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | |
| 6 | F (C) | Activated factor Xa heavy chain | polymer | 254 | 28550.6 | 1 | UniProt (P00742) Pfam (PF00089) | Homo sapiens (human) | |
| 7 | G (B) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 8 | H (D) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 9 | I, J (D, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 1 - 278 (UniProt: Q5WPU8)
| PDB | External Database | Details |
|---|---|---|
| Arg 75 | Lys 98 | conflict |
| Ser 134 | Pro 157 | conflict |
| Leu 145 | Val 168 | conflict |
| Asn 148 | Tyr 171 | conflict |
| His 279 | - | expression tag |
| His 280 | - | expression tag |
| His 281 | - | expression tag |
| His 282 | - | expression tag |
| His 283 | - | expression tag |
| His 284 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 338093.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 466.7 | |
| All* | Total formula weight | 339146.3 |
