8EOK

Structure of the C3bB proconvertase in complex with lufaxin and factor Xa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0006508	biological_process	proteolysis
D	0006956	biological_process	complement activation
G	0004866	molecular_function	endopeptidase inhibitor activity
H	0004866	molecular_function	endopeptidase inhibitor activity
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
L	0005509	molecular_function	calcium ion binding
L	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDglgeYtCtC

Chain	Residue	Details
L	CYS61-CYS72

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site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EcmEEtCsyeearEvfedsdktne.FW

Chain	Residue	Details
L	GLU16-TRP41

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CtCleGfeGKnC

Chain	Residue	Details
L	CYS70-CYS81

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site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
C	LEU53-CYS58
D	LEU497-CYS502

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPHV

Chain	Residue	Details
C	ASP189-VAL200
D	ASN668-ILE679

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site_id	PS00477
Number of Residues	9
Details	ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM

Chain	Residue	Details
H	PRO985-MET993

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site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CtCleGFegkn....C

Chain	Residue	Details
L	CYS70-CYS81
L	CYS109-CYS124

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site_id	PS01187
Number of Residues	25
Details	EGF_CA Calcium-binding EGF-like domain signature. DgDQCetsp..........Cqnqgk..CkDglgeYtC

Chain	Residue	Details
L	ASP46-CYS70

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
C	HIS57
L	GLU32
L	GLU39
C	ASP102
C	SER195
L	GLU16
L	GLU19
L	GLU20
L	GLU25
L	GLU26
L	GLU29

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: (3R)-3-hydroxyaspartate => ECO:0000269|PubMed:6871167

Chain	Residue	Details
L	ASP63
D	ASN260
G	SER275
G	SER281

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754

Chain	Residue	Details
D	ASN117

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911

Chain	Residue	Details
D	LYS266
H	SER1299
H	SER1551

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754

Chain	Residue	Details
D	ASN353

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
H	ASN1595

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln)

Chain	Residue	Details
H	CYS988
H	GLN991

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