8EJM

Crystal structure of human DEAH-box helicase DHX15 in complex with SUGP1 G-patch

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ATP-dependent RNA helicase DHX15	polymer	686	78730.4	1	UniProt (O43143) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717) In PDB	Homo sapiens (human)	ATP-dependent RNA helicase #46,DEAH box protein 15,Splicing factor Prp43,hPrp43
2	B	SURP and G-patch domain-containing protein 1	polymer	74	8094.0	1	UniProt (Q8IWZ8) Pfam (PF01585) In PDB	Homo sapiens (human)	RNA-binding protein RBP,Splicing factor 4
3	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
4	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7	A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
8		water	water		18.0	273	Chemie (HOH)

Sequence modifications

A: 113 - 795 (UniProt: O43143)

PDB	External Database	Details
Ser 110	-	expression tag
Asn 111	-	expression tag
Met 112	-	expression tag

B: 543 - 614 (UniProt: Q8IWZ8)

PDB	External Database	Details
Ser 541	-	expression tag
Asn 542	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	86824.4
Non-Polymers*	Number of molecules	8
	Total formula weight	898.7
All*	Total formula weight	87723.1

*Water molecules are not included.