8DMK
Cryo-EM reveals the molecular basis of laminin polymerization and LN-lamininopathies
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Laminin subunit alpha-1 | polymer | 305 | 34709.2 | 1 | UniProt (P19137) Pfam (PF00055) Pfam (PF00053) In PDB | Mus musculus (mouse) | Laminin A chain,Laminin-1 subunit alpha,Laminin-3 subunit alpha,S-laminin subunit alpha,S-LAM alpha |
| 2 | B | Laminin subunit beta-1 | polymer | 307 | 35091.9 | 1 | UniProt (P07942) Pfam (PF00055) Pfam (PF00053) In PDB | Homo sapiens (human) | Laminin B1 chain,Laminin-1 subunit beta,Laminin-10 subunit beta,Laminin-12 subunit beta,Laminin-2 subunit beta,Laminin-6 subunit beta,Laminin-8 subunit beta |
| 3 | G | Laminin subunit gamma-1 | polymer | 305 | 34110.8 | 1 | UniProt (P11047) Pfam (PF00055) Pfam (PF00053) In PDB | Homo sapiens (human) | |
| 4 | A, B, G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 5 | G | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) |
Sequence modifications
G: 37 - 341 (UniProt: P11047)
| PDB | External Database | Details |
|---|---|---|
| Trp 167 | Arg 167 | conflict |
| Ser 250 | Arg 250 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 103911.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1146.1 | |
| All* | Total formula weight | 105058.1 |
