8DIV
Crystal structure of NavAb I22V as a basis for the human Nav1.7 Inherited Erythromelalgia I136V mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ion transport protein | polymer | 257 | 29775.3 | 1 | UniProt (A8EVM5) Pfam (PF00520) Pfam (PF08016) | Aliarcobacter butzleri RM4018 | |
| 2 | B (A) | beta-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (BGC) | |||
| 3 | C, D, E, F, G (A) | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 678.9 | 5 | Chemie (PX4) | |||
| 4 | H, I (A) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 2 | Chemie (CPS) | |||
| 5 | J (A) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 1001 - 1239 (UniProt: A8EVM5)
| PDB | External Database | Details |
|---|---|---|
| Met 983 | - | initiating methionine |
| Asp 984 | - | expression tag |
| Tyr 985 | - | expression tag |
| Lys 986 | - | expression tag |
| Asp 987 | - | expression tag |
| Asp 988 | - | expression tag |
| Asp 989 | - | expression tag |
| Asp 990 | - | expression tag |
| Lys 991 | - | expression tag |
| Gly 992 | - | expression tag |
| Ser 993 | - | expression tag |
| Leu 994 | - | expression tag |
| Val 995 | - | expression tag |
| Pro 996 | - | expression tag |
| Arg 997 | - | expression tag |
| Gly 998 | - | expression tag |
| Ser 999 | - | expression tag |
| His 1000 | - | expression tag |
| Val 1022 | Ile 22 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29775.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4804.6 | |
| All* | Total formula weight | 34579.9 |
