8DHA

Leptin-bound leptin receptor complex- focused interaction

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Leptin receptor	polymer	555	63445.5	2	UniProt (P48356) Pfam (PF06328) Pfam (PF18589)	Mus musculus (house mouse)	LEP-R,B219,OB receptor,OB-R
2	C (C)	Leptin	polymer	146	16018.3	1	UniProt (P41160) Pfam (PF02024)	Mus musculus (house mouse)	Obesity factor
3	D, E (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A, B: 330 - 839 (UniProt: P48356)

PDB	External Database	Details
Gly 840	-	expression tag
Ser 841	-	expression tag
Gly 842	-	expression tag
Gly 843	-	expression tag
Met 844	-	expression tag
Lys 845	-	expression tag
Gln 846	-	expression tag
Leu 847	-	expression tag
Glu 848	-	expression tag
Asp 849	-	expression tag
Lys 850	-	expression tag
Val 851	-	expression tag
Glu 852	-	expression tag
Glu 853	-	expression tag
Leu 854	-	expression tag
Leu 855	-	expression tag
Ser 856	-	expression tag
Lys 857	-	expression tag
Asn 858	-	expression tag
Tyr 859	-	expression tag
His 860	-	expression tag
Leu 861	-	expression tag
Glu 862	-	expression tag
Asn 863	-	expression tag
Glu 864	-	expression tag
Val 865	-	expression tag
Ala 866	-	expression tag
Arg 867	-	expression tag
Leu 868	-	expression tag
Lys 869	-	expression tag
Lys 870	-	expression tag
Leu 871	-	expression tag
Val 872	-	expression tag
Gly 873	-	expression tag
Glu 874	-	expression tag
Arg 875	-	expression tag
Ser 876	-	expression tag
Gly 877	-	expression tag
Gly 878	-	expression tag
His 879	-	expression tag
His 880	-	expression tag
His 881	-	expression tag
His 882	-	expression tag
His 883	-	expression tag
His 884	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	142909.3
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	143351.7

*Water molecules are not included.