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8DHA

Leptin-bound leptin receptor complex- focused interaction

Functional Information from GO Data
ChainGOidnamespacecontents
A0003700molecular_functionDNA-binding transcription factor activity
A0004896molecular_functioncytokine receptor activity
A0006355biological_processregulation of DNA-templated transcription
A0016020cellular_componentmembrane
B0003700molecular_functionDNA-binding transcription factor activity
B0004896molecular_functioncytokine receptor activity
B0006355biological_processregulation of DNA-templated transcription
B0016020cellular_componentmembrane
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001525biological_processangiogenesis
C0001542biological_processovulation from ovarian follicle
C0001666biological_processresponse to hypoxia
C0001819biological_processpositive regulation of cytokine production
C0001890biological_processplacenta development
C0001934biological_processpositive regulation of protein phosphorylation
C0001936biological_processregulation of endothelial cell proliferation
C0002021biological_processresponse to dietary excess
C0003300biological_processcardiac muscle hypertrophy
C0003677molecular_functionDNA binding
C0005102molecular_functionsignaling receptor binding
C0005179molecular_functionhormone activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006006biological_processglucose metabolic process
C0006111biological_processregulation of gluconeogenesis
C0006112biological_processenergy reserve metabolic process
C0006114biological_processglycerol biosynthetic process
C0006629biological_processlipid metabolic process
C0006635biological_processfatty acid beta-oxidation
C0006909biological_processphagocytosis
C0007165biological_processsignal transduction
C0007259biological_processcell surface receptor signaling pathway via JAK-STAT
C0007565biological_processfemale pregnancy
C0007584biological_processresponse to nutrient
C0007623biological_processcircadian rhythm
C0008203biological_processcholesterol metabolic process
C0008206biological_processbile acid metabolic process
C0008217biological_processregulation of blood pressure
C0008284biological_processpositive regulation of cell population proliferation
C0008340biological_processdetermination of adult lifespan
C0008343biological_processadult feeding behavior
C0009062biological_processfatty acid catabolic process
C0009892biological_processnegative regulation of metabolic process
C0010507biological_processnegative regulation of autophagy
C0010888biological_processnegative regulation of lipid storage
C0014823biological_processresponse to activity
C0019222biological_processregulation of metabolic process
C0019953biological_processsexual reproduction
C0021954biological_processcentral nervous system neuron development
C0030073biological_processinsulin secretion
C0030217biological_processT cell differentiation
C0030300biological_processregulation of intestinal cholesterol absorption
C0031667biological_processresponse to nutrient levels
C0032008biological_processpositive regulation of TOR signaling
C0032099biological_processnegative regulation of appetite
C0032310biological_processprostaglandin secretion
C0032355biological_processresponse to estradiol
C0032735biological_processpositive regulation of interleukin-12 production
C0032755biological_processpositive regulation of interleukin-6 production
C0032757biological_processpositive regulation of interleukin-8 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0032814biological_processregulation of natural killer cell activation
C0032817biological_processregulation of natural killer cell proliferation
C0032868biological_processresponse to insulin
C0032869biological_processcellular response to insulin stimulus
C0033197biological_processresponse to vitamin E
C0033210biological_processleptin-mediated signaling pathway
C0033686biological_processpositive regulation of luteinizing hormone secretion
C0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
C0035556biological_processintracellular signal transduction
C0035630biological_processbone mineralization involved in bone maturation
C0035904biological_processaorta development
C0038108biological_processnegative regulation of appetite by leptin-mediated signaling pathway
C0042102biological_processpositive regulation of T cell proliferation
C0042269biological_processregulation of natural killer cell mediated cytotoxicity
C0042307biological_processpositive regulation of protein import into nucleus
C0042445biological_processhormone metabolic process
C0042593biological_processglucose homeostasis
C0042755biological_processeating behavior
C0043066biological_processnegative regulation of apoptotic process
C0043270biological_processpositive regulation of monoatomic ion transport
C0043410biological_processpositive regulation of MAPK cascade
C0044320biological_processcellular response to leptin stimulus
C0045471biological_processresponse to ethanol
C0045598biological_processregulation of fat cell differentiation
C0045765biological_processregulation of angiogenesis
C0045906biological_processnegative regulation of vasoconstriction
C0046325biological_processnegative regulation of D-glucose import
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046628biological_processpositive regulation of insulin receptor signaling pathway
C0046850biological_processregulation of bone remodeling
C0046881biological_processpositive regulation of follicle-stimulating hormone secretion
C0046890biological_processregulation of lipid biosynthetic process
C0048639biological_processpositive regulation of developmental growth
C0050796biological_processregulation of insulin secretion
C0050810biological_processregulation of steroid biosynthetic process
C0050892biological_processintestinal absorption
C0050901biological_processleukocyte tethering or rolling
C0050999biological_processregulation of nitric-oxide synthase activity
C0051428molecular_functionpeptide hormone receptor binding
C0051541biological_processelastin metabolic process
C0051726biological_processregulation of cell cycle
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0060587biological_processregulation of lipoprotein lipid oxidation
C0060612biological_processadipose tissue development
C0061037biological_processnegative regulation of cartilage development
C0070093biological_processnegative regulation of glucagon secretion
C0071298biological_processcellular response to L-ascorbic acid
C0071300biological_processcellular response to retinoic acid
C0090335biological_processregulation of brown fat cell differentiation
C0097009biological_processenergy homeostasis
C0098868biological_processbone growth
C0120162biological_processpositive regulation of cold-induced thermogenesis
C1900015biological_processregulation of cytokine production involved in inflammatory response
C1900180biological_processregulation of protein localization to nucleus
C1900745biological_processpositive regulation of p38MAPK cascade
C1904651biological_processpositive regulation of fat cell apoptotic process
C1990051biological_processactivation of protein kinase C activity
C1990460molecular_functionleptin receptor binding
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
C2000486biological_processnegative regulation of glutamine transport
C2000491biological_processpositive regulation of hepatic stellate cell activation
Functional Information from PROSITE/UniProt
site_idPS01353
Number of Residues57
DetailsHEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NslgaSlvnfnltfswpmskvsaveslsayplssscvi...LsWtlsPddysll...YlvIeW
ChainResidueDetails
AASN716-TRP772

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN345
AASN726
BASN345
BASN431
BASN514
BASN622
BASN657
BASN668
BASN686
BASN695
BASN698
AASN431
BASN726
AASN514
AASN622
AASN657
AASN668
AASN686
AASN695
AASN698

226262

PDB entries from 2024-10-16

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