8DGQ
Crystal structure of p120RasGAP SH2-SH3-SH2 in complex with p190RhoGAP doubly phosphorylated peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ras GTPase-activating protein 1 | polymer | 273 | 31551.5 | 2 | UniProt (P20936) Pfam (PF00017) Pfam (PF00018) | Homo sapiens (human) | GAP,GTPase-activating protein,RasGAP,Ras p21 protein activator,p120GAP |
| 2 | C, D (U, V) | Rho GTPase-activating protein 35 | polymer | 29 | 3467.4 | 2 | UniProt (Q9NRY4) | Homo sapiens | Glucocorticoid receptor DNA-binding factor 1,Glucocorticoid receptor repression factor 1,GRF-1,Rho GAP p190A,p190-A |
| 3 | E, F, G (A, B) | MALONATE ION | non-polymer | 102.0 | 3 | Chemie (MLI) | |||
| 4 | H, I, J, K (A, B, U, V) | water | water | 18.0 | 233 | Chemie (HOH) |
Sequence modifications
A, B: 174 - 444 (UniProt: P20936)
| PDB | External Database | Details |
|---|---|---|
| Gly 172 | - | expression tag |
| Ser 173 | - | expression tag |
| Ser 236 | Cys 236 | conflict |
| Ser 261 | Cys 261 | conflict |
| Ser 372 | Cys 372 | conflict |
| Ser 402 | Cys 402 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 70038.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 306.1 | |
| All* | Total formula weight | 70344.1 |
