8D58
Crystal structure of human METTL1-WDR4 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | tRNA (guanine-N(7)-)-methyltransferase | polymer | 246 | 28456.6 | 1 | UniProt (Q9UBP6) Pfam (PF02390) In PDB | Homo sapiens (human) | Methyltransferase-like protein 1,mRNA (guanine-N(7)-)-methyltransferase,miRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine(46)-N(7))-methyltransferase,tRNA(m7G46)-methyltransferase |
2 | B | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 | polymer | 405 | 45123.0 | 1 | UniProt (P57081) Pfam (PF00400) In PDB | Homo sapiens (human) | Protein Wuho homolog,hWH,WD repeat-containing protein 4 |
3 | A, B | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
4 | A, B | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 2 | Chemie (IPA) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
B: 1 - 389 (UniProt: P57081)
PDB | External Database | Details |
---|---|---|
Met -15 | - | initiating methionine |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 73579.6 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 425.0 | |
All* | Total formula weight | 74004.6 |