8D58
Crystal structure of human METTL1-WDR4 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006400 | biological_process | tRNA modification |
| A | 0008176 | molecular_function | tRNA (guanine(46)-N7)-methyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005694 | cellular_component | chromosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006400 | biological_process | tRNA modification |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008033 | biological_process | tRNA processing |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0036265 | biological_process | RNA (guanine-N7)-methylation |
| B | 0043527 | cellular_component | tRNA methyltransferase complex |
| B | 0106004 | biological_process | tRNA (guanine-N7)-methylation |
| B | 0106143 | cellular_component | tRNA (m7G46) methyltransferase complex |
| B | 0141106 | molecular_function | tRNA methyltransferase activator activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.6 |
| Chain | Residue | Details |
| B | ALA2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36599982, ECO:0000269|Ref.19, ECO:0007744|PDB:3CKK, ECO:0007744|PDB:8D9L |
| Chain | Residue | Details |
| A | GLY84 | |
| A | GLU107 | |
| A | ASN140 | |
| A | THR238 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36599985, ECO:0007744|PDB:8CTH |
| Chain | Residue | Details |
| A | ILE108 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|Ref.19, ECO:0007744|PDB:3CKK |
| Chain | Residue | Details |
| A | ARG109 | |
| A | ALA141 | |
| A | LEU160 | |
| A | GLU240 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKB/AKT1 and RPS6KA3 => ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:36599985, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER27 |
