8D51
Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing beta-3-homotryptophan
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Parathyroid hormone/parathyroid hormone-related peptide receptor | polymer | 103 | 11995.7 | 1 | UniProt (Q03431) Pfam (PF02793) | Homo sapiens (human) | PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor |
| 2 | B (B) | PTHrP[1-36] | polymer | 22 | 2822.3 | 1 | UniProt (P12272) | Homo sapiens | |
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 29 - 174 (UniProt: Q03431)
B: 15 - 36 (UniProt: P12272)
| PDB | External Database | Details |
|---|---|---|
| Gly 28 | - | expression tag |
| - | Ser 61 | deletion |
| - | Ile 62 | deletion |
| - | Met 63 | deletion |
| - | Glu 64 | deletion |
| - | Ser 65 | deletion |
| - | Asp 66 | deletion |
| - | Lys 67 | deletion |
| - | Gly 68 | deletion |
| - | Trp 69 | deletion |
| - | Thr 70 | deletion |
| - | Ser 71 | deletion |
| - | Ala 72 | deletion |
| - | Ser 73 | deletion |
| - | Thr 74 | deletion |
| - | Ser 75 | deletion |
| - | Gly 76 | deletion |
| - | Lys 77 | deletion |
| - | Pro 78 | deletion |
| - | Arg 79 | deletion |
| - | Lys 80 | deletion |
| - | Asp 81 | deletion |
| - | Lys 82 | deletion |
| - | Ala 83 | deletion |
| - | Ser 84 | deletion |
| - | Gly 85 | deletion |
| - | Lys 86 | deletion |
| - | Leu 87 | deletion |
| - | Tyr 88 | deletion |
| - | Pro 89 | deletion |
| - | Glu 90 | deletion |
| - | Ser 91 | deletion |
| - | Glu 92 | deletion |
| - | Glu 93 | deletion |
| - | Asp 94 | deletion |
| - | Lys 95 | deletion |
| - | Glu 96 | deletion |
| - | Ala 97 | deletion |
| - | Pro 98 | deletion |
| - | Thr 99 | deletion |
| - | Gly 100 | deletion |
| - | Ser 101 | deletion |
| - | Arg 102 | deletion |
| - | Tyr 103 | deletion |
| - | Arg 104 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Ht7 31 | Ile 67 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 14817.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 127.5 | |
| All* | Total formula weight | 14945.4 |
