8CZA
Crystal structure of the first bromodomain (BD1) of human BRDT bound to GXH-IV-075
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Bromodomain testis-specific protein | polymer | 113 | 13319.4 | 6 | UniProt (Q58F21) Pfam (PF00439) | Homo sapiens (human) | Cancer/testis antigen 9,CT9,RING3-like protein |
| 2 | G, H, K (B, C, F) | 4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluoro-N-[1-(14-{3-[(2-{3-fluoro-4-[(piperidin-4-yl)carbamoyl]anilino}-5-methylpyrimidin-4-yl)amino]-5-[(2-methylpropane-2-sulfonyl)amino]phenyl}-14-oxo-4,7,10-trioxa-13-azatetradecanan-1-oyl)piperidin-4-yl]benzamide | non-polymer | 1375.0 | 3 | Chemie (ZN1) | |||
| 3 | I, J (C, D) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | L, M, N (B, E, F) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 29 - 137 (UniProt: Q58F21)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Ala 26 | - | expression tag |
| Ala 27 | - | expression tag |
| Ser 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 79916.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 4171.0 | |
| All* | Total formula weight | 84087.2 |
