8CLS

Drosophila melanogaster insulin receptor ectodomain in complex with DILP5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Insulin-like receptor	polymer	1068	120074.6	2	UniProt (P09208) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) In PDB	Drosophila melanogaster (fruit fly)	dIR,dInr,dIRH
2	C, E, G	Probable insulin-like peptide 5 A chain	polymer	25	2795.1	3	UniProt (Q7KUD5) In PDB	Drosophila melanogaster
3	D, F, H	Probable insulin-like peptide 5	polymer	28	3018.6	3	UniProt (Q7KUD5) Pfam (PF00049) In PDB	Drosophila melanogaster	dILP5,Insulin-related peptide 5

Sequence modifications

A, B: 264 - 1310 (UniProt: P09208)

PDB	External Database	Details
Met 263	-	initiating methionine
Asp 1311	-	expression tag
Glu 1312	-	expression tag
Val 1313	-	expression tag
Leu 1314	-	expression tag
Phe 1315	-	expression tag
Gln 1316	-	expression tag
Gly 1317	-	expression tag
Pro 1318	-	expression tag
Ser 1319	-	expression tag
Arg 1320	-	expression tag
Ser 1321	-	expression tag
Ala 1322	-	expression tag
Trp 1323	-	expression tag
Ser 1324	-	expression tag
His 1325	-	expression tag
Pro 1326	-	expression tag
Gln 1327	-	expression tag
Phe 1328	-	expression tag
Glu 1329	-	expression tag
Lys 1330	-	expression tag

C, E, G: 1 - 25 (UniProt: Q7KUD5)

PDB	External Database	Details
Asn 12	Lys 95	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	257590.4
All*	Total formula weight	257590.4

*Water molecules are not included.