8BYA
Cryo-EM structure of SKP1-SKP2-CKS1-CDK2-CyclinA-p27KIP1 Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cyclin-dependent kinase 2 | polymer | 298 | 33994.4 | 1 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B | Cyclin-A2 | polymer | 432 | 48609.6 | 1 | UniProt (P20248) Pfam (PF16500) Pfam (PF00134) Pfam (PF02984) In PDB | Homo sapiens (human) | Cyclin-A,Cyclin A |
| 3 | C | Cyclin-dependent kinase inhibitor 1B | polymer | 158 | 17678.5 | 1 | UniProt (O43806) Pfam (PF02234) UniProt (by SIFTS) (P46527) In PDB | Homo sapiens (human) | Cyclin-dependent kinase inhibitor p27,p27Kip1 |
| 4 | D | S-phase kinase-associated protein 1 | polymer | 163 | 18680.0 | 1 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) In PDB | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
| 5 | E | S-phase kinase-associated protein 2 | polymer | 424 | 47817.8 | 1 | UniProt (Q13309) Pfam (PF12937) In PDB | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p45,F-box protein Skp2,F-box/LRR-repeat protein 1,p45skp2 |
| 6 | F | Cyclin-dependent kinases regulatory subunit 1 | polymer | 79 | 9679.2 | 1 | UniProt (P61024) Pfam (PF01111) In PDB | Homo sapiens (human) | CKS-1 |
| 7 | G | p27 KIP1 C-terminus | polymer | 10 | 1126.2 | 1 | UniProt (by SIFTS) (P46527) In PDB | Homo sapiens (human) |
Sequence modifications
A: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Tpo 159 | Tyr 159 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 177585.6 | |
| All* | Total formula weight | 177585.6 |
