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8BYA

Cryo-EM structure of SKP1-SKP2-CKS1-CDK2-CyclinA-p27KIP1 Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000086biological_processG2/M transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000287molecular_functionmagnesium ion binding
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0000781cellular_componentchromosome, telomeric region
A0000793cellular_componentcondensed chromosome
A0000805cellular_componentX chromosome
A0000806cellular_componentY chromosome
A0001673cellular_componentmale germ cell nucleus
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006260biological_processDNA replication
A0006281biological_processDNA repair
A0006338biological_processchromatin remodeling
A0006351biological_processDNA-templated transcription
A0006468biological_processprotein phosphorylation
A0006813biological_processpotassium ion transport
A0007099biological_processcentriole replication
A0007165biological_processsignal transduction
A0007265biological_processRas protein signal transduction
A0007346biological_processregulation of mitotic cell cycle
A0008284biological_processpositive regulation of cell population proliferation
A0010389biological_processregulation of G2/M transition of mitotic cell cycle
A0010468biological_processregulation of gene expression
A0015030cellular_componentCajal body
A0016301molecular_functionkinase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0019904molecular_functionprotein domain specific binding
A0030332molecular_functioncyclin binding
A0031453biological_processpositive regulation of heterochromatin formation
A0031571biological_processmitotic G1 DNA damage checkpoint signaling
A0032298biological_processpositive regulation of DNA-templated DNA replication initiation
A0035173molecular_functionhistone kinase activity
A0043247biological_processtelomere maintenance in response to DNA damage
A0043687biological_processpost-translational protein modification
A0045740biological_processpositive regulation of DNA replication
A0045893biological_processpositive regulation of DNA-templated transcription
A0046872molecular_functionmetal ion binding
A0051298biological_processcentrosome duplication
A0051301biological_processcell division
A0051321biological_processmeiotic cell cycle
A0071732biological_processcellular response to nitric oxide
A0090398biological_processcellular senescence
A0097123cellular_componentcyclin A1-CDK2 complex
A0097124cellular_componentcyclin A2-CDK2 complex
A0097134cellular_componentcyclin E1-CDK2 complex
A0097135cellular_componentcyclin E2-CDK2 complex
A0097472molecular_functioncyclin-dependent protein kinase activity
A0106310molecular_functionprotein serine kinase activity
A1905784biological_processregulation of anaphase-promoting complex-dependent catabolic process
B0000082biological_processG1/S transition of mitotic cell cycle
B0000086biological_processG2/M transition of mitotic cell cycle
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0001939cellular_componentfemale pronucleus
B0001940cellular_componentmale pronucleus
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0006275biological_processregulation of DNA replication
B0006351biological_processDNA-templated transcription
B0007265biological_processRas protein signal transduction
B0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0031100biological_processanimal organ regeneration
B0032355biological_processresponse to estradiol
B0033762biological_processresponse to glucagon
B0036120biological_processcellular response to platelet-derived growth factor stimulus
B0043687biological_processpost-translational protein modification
B0044320biological_processcellular response to leptin stimulus
B0044772biological_processmitotic cell cycle phase transition
B0044843biological_processcell cycle G1/S phase transition
B0045893biological_processpositive regulation of DNA-templated transcription
B0048146biological_processpositive regulation of fibroblast proliferation
B0051301biological_processcell division
B0071314biological_processcellular response to cocaine
B0071373biological_processcellular response to luteinizing hormone stimulus
B0071392biological_processcellular response to estradiol stimulus
B0071407biological_processcellular response to organic cyclic compound
B0071456biological_processcellular response to hypoxia
B0071732biological_processcellular response to nitric oxide
B0090102biological_processcochlea development
B0097122cellular_componentcyclin A2-CDK1 complex
B0097124cellular_componentcyclin A2-CDK2 complex
B1990314biological_processcellular response to insulin-like growth factor stimulus
B2000573biological_processpositive regulation of DNA biosynthetic process
C0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
C0005634cellular_componentnucleus
C0051726biological_processregulation of cell cycle
D0000209biological_processprotein polyubiquitination
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0006338biological_processchromatin remodeling
D0006511biological_processubiquitin-dependent protein catabolic process
D0006513biological_processprotein monoubiquitination
D0008013molecular_functionbeta-catenin binding
D0016567biological_processprotein ubiquitination
D0019005cellular_componentSCF ubiquitin ligase complex
D0019904molecular_functionprotein domain specific binding
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031467cellular_componentCul7-RING ubiquitin ligase complex
D0031519cellular_componentPcG protein complex
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051457biological_processmaintenance of protein location in nucleus
D0070936biological_processprotein K48-linked ubiquitination
D0097602molecular_functioncullin family protein binding
D0140677molecular_functionmolecular function activator activity
D0160072molecular_functionubiquitin ligase complex scaffold activity
D1904668biological_processpositive regulation of ubiquitin protein ligase activity
D1990444molecular_functionF-box domain binding
D1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
E0000082biological_processG1/S transition of mitotic cell cycle
E0000086biological_processG2/M transition of mitotic cell cycle
E0000209biological_processprotein polyubiquitination
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006511biological_processubiquitin-dependent protein catabolic process
E0016567biological_processprotein ubiquitination
E0019005cellular_componentSCF ubiquitin ligase complex
E0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E0033148biological_processpositive regulation of intracellular estrogen receptor signaling pathway
E0042802molecular_functionidentical protein binding
E0042981biological_processregulation of apoptotic process
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0045087biological_processinnate immune response
E0051607biological_processdefense response to virus
E0051726biological_processregulation of cell cycle
E0070534biological_processprotein K63-linked ubiquitination
E0070936biological_processprotein K48-linked ubiquitination
E1902916biological_processpositive regulation of protein polyubiquitination
E1905168biological_processpositive regulation of double-strand break repair via homologous recombination
E1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
F0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
F0005515molecular_functionprotein binding
F0005654cellular_componentnucleoplasm
F0006355biological_processregulation of DNA-templated transcription
F0007346biological_processregulation of mitotic cell cycle
F0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
F0019005cellular_componentSCF ubiquitin ligase complex
F0019901molecular_functionprotein kinase binding
F0042393molecular_functionhistone binding
F0043130molecular_functionubiquitin binding
F0044772biological_processmitotic cell cycle phase transition
F0048144biological_processfibroblast proliferation
F0051301biological_processcell division
F0061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK
ChainResidueDetails
AILE10-LYS33

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
ChainResidueDetails
AVAL123-ILE135

site_idPS00292
Number of Residues32
DetailsCYCLINS Cyclins signature. RaiLvdWLvevgeeykLqnetLhlAVnYIDRF
ChainResidueDetails
BARG211-PHE242

site_idPS00944
Number of Residues19
DetailsCKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYdDEeFEYRHVmLPK
ChainResidueDetails
FTYR3008-LYS3026

site_idPS00945
Number of Residues11
DetailsCKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR
ChainResidueDetails
FHIS3060-ARG3070

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PKB/AKT1, CDK1 and CDK2 => ECO:0000269|PubMed:10323868, ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:16209941, ECO:0000269|PubMed:23478441
ChainResidueDetails
GTPO4187

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:17254967
ChainResidueDetails
CTYR74
ELYS2071
AGLU81
AASP86
ALYS129

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by ABL, LYN, SRC and JAK2 => ECO:0000269|PubMed:16195327, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:17254967, ECO:0000269|PubMed:21423214
ChainResidueDetails
CTYR88
ESER2075

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:16195327
ChainResidueDetails
CTYR89
ALYS88
ALEU166

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CaMK1, PKB/AKT1 and PIM1 => ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:12244303, ECO:0000269|PubMed:18593906, ECO:0000269|PubMed:23707388
ChainResidueDetails
CTHR157

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS6

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507
ChainResidueDetails
ATHR14

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by WEE1 => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507, ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR15

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ATYR19

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CAK and CCRK => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:14597612, ECO:0000269|PubMed:16325401, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:17570665, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:21565702, ECO:0000305|PubMed:28666995
ChainResidueDetails
ATHR160

222624

PDB entries from 2024-07-17

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