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Cryo-EM structure of NHEJ supercomplex(trimer)

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, D, E
(K, L, N, O)
DNA repair protein XRCC4polymer33638337.74UniProt (Q13426)
Pfam (PF06632)
Pfam (PF21924)
Pfam (PF21925)
Homo sapiens (human)X-ray repair cross-complementing protein 4
2C, F
(M, P)
DNA ligase 4polymer911104125.02UniProt (P49917)
Pfam (PF04675)
Pfam (PF01068)
Pfam (PF04679)
Pfam (PF00533)
Pfam (PF11411)
Homo sapiens (human)DNA ligase IV,Polydeoxyribonucleotide synthase [ATP] 4
3G, H, X, Y
(Q, R, X, Y)
Non-homologous end-joining factor 1polymer29933372.24UniProt (Q9H9Q4)
Pfam (PF09302)
Pfam (PF21928)
Homo sapiens (human)Protein cernunnos,XRCC4-like factor
4I, N, S
(F, A, S)
DNA-dependent protein kinase catalytic subunitpolymer4128469673.23UniProt (P78527)
Pfam (PF20502)
Pfam (PF08163)
Pfam (PF19704)
Pfam (PF02259)
Pfam (PF00454)
Pfam (PF02260)
Homo sapiens (human)DNA-PK catalytic subunit,DNA-PKcs,DNPK1,p460
5J, O, T
(G, B, T)
X-ray repair cross-complementing protein 6polymer60969945.03UniProt (P12956)
Pfam (PF02037)
Pfam (PF03731)
Pfam (PF02735)
Pfam (PF03730)
Homo sapiens (human)5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,CTCBF,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Ku70,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 6
6K, P, U
(H, C, U)
X-ray repair cross-complementing protein 5polymer73282812.43UniProt (P13010)
Pfam (PF03731)
Pfam (PF02735)
Pfam (PF03730)
Pfam (PF08785)
Homo sapiens (human)86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTCBF,DNA repair protein XRCC5,Ku80,Ku86,Lupus Ku autoantigen protein p86,Nuclear factor IV,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
7L, V
(I, V)
DNA (28-MER)polymer288619.62Homo sapiens
8M, W
(J, W)
DNA (27-MER)polymer278350.42Homo sapiens
9Q
(D)
DNA (24-MER)polymer247367.81Homo sapiens
10R
(E)
DNA (24-MER)polymer247402.81Homo sapiens
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains25
Total formula weight2411092.5
All*Total formula weight2411092.5
*Water molecules are not included.

237423

PDB entries from 2025-06-11

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