8BOT

Cryo-EM structure of NHEJ supercomplex(trimer)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000460	biological_process	maturation of 5.8S rRNA
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0001756	biological_process	somitogenesis
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0002218	biological_process	activation of innate immune response
A	0002326	biological_process	B cell lineage commitment
A	0002327	biological_process	immature B cell differentiation
A	0002328	biological_process	pro-B cell differentiation
A	0002360	biological_process	T cell lineage commitment
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004677	molecular_function	DNA-dependent protein kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005730	cellular_component	nucleolus
A	0005829	cellular_component	cytosol
A	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
A	0006281	biological_process	DNA repair
A	0006302	biological_process	double-strand break repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006310	biological_process	DNA recombination
A	0006338	biological_process	chromatin remodeling
A	0006468	biological_process	protein phosphorylation
A	0006974	biological_process	DNA damage response
A	0007420	biological_process	brain development
A	0007507	biological_process	heart development
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0010212	biological_process	response to ionizing radiation
A	0010332	biological_process	response to gamma radiation
A	0016020	cellular_component	membrane
A	0016233	biological_process	telomere capping
A	0016301	molecular_function	kinase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0018107	biological_process	peptidyl-threonine phosphorylation
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0030098	biological_process	lymphocyte differentiation
A	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
A	0031648	biological_process	protein destabilization
A	0032040	cellular_component	small-subunit processome
A	0032869	biological_process	cellular response to insulin stimulus
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0033077	biological_process	T cell differentiation in thymus
A	0033151	biological_process	V(D)J recombination
A	0033152	biological_process	immunoglobulin V(D)J recombination
A	0033153	biological_process	T cell receptor V(D)J recombination
A	0034462	biological_process	small-subunit processome assembly
A	0034511	molecular_function	U3 snoRNA binding
A	0035234	biological_process	ectopic germ cell programmed cell death
A	0035979	molecular_function	histone H2AXS139 kinase activity
A	0036211	biological_process	protein modification process
A	0042254	biological_process	ribosome biogenesis
A	0042752	biological_process	regulation of circadian rhythm
A	0043065	biological_process	positive regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0045087	biological_process	innate immune response
A	0045621	biological_process	positive regulation of lymphocyte differentiation
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045727	biological_process	positive regulation of translation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048511	biological_process	rhythmic process
A	0048660	biological_process	regulation of smooth muscle cell proliferation
A	0050678	biological_process	regulation of epithelial cell proliferation
A	0060255	biological_process	regulation of macromolecule metabolic process
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070418	cellular_component	DNA-dependent protein kinase complex
A	0070419	cellular_component	nonhomologous end joining complex
A	0080090	biological_process	regulation of primary metabolic process
A	0080135	biological_process	regulation of cellular response to stress
A	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
A	0106310	molecular_function	protein serine kinase activity
A	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
A	1902036	biological_process	regulation of hematopoietic stem cell differentiation
A	1905221	biological_process	positive regulation of platelet formation
A	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
B	0000723	biological_process	telomere maintenance
B	0000725	biological_process	recombinational repair
B	0000781	cellular_component	chromosome, telomeric region
B	0000783	cellular_component	nuclear telomere cap complex
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0002218	biological_process	activation of innate immune response
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003691	molecular_function	double-stranded telomeric DNA binding
B	0003723	molecular_function	RNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005667	cellular_component	transcription regulator complex
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005829	cellular_component	cytosol
B	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
B	0006266	biological_process	DNA ligation
B	0006281	biological_process	DNA repair
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0010558	biological_process	negative regulation of macromolecule biosynthetic process
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030332	molecular_function	cyclin binding
B	0032508	biological_process	DNA duplex unwinding
B	0032991	cellular_component	protein-containing complex
B	0032993	cellular_component	protein-DNA complex
B	0034774	cellular_component	secretory granule lumen
B	0042162	molecular_function	telomeric DNA binding
B	0043564	cellular_component	Ku70:Ku80 complex
B	0044877	molecular_function	protein-containing complex binding
B	0045027	molecular_function	DNA end binding
B	0045087	biological_process	innate immune response
B	0045621	biological_process	positive regulation of lymphocyte differentiation
B	0045860	biological_process	positive regulation of protein kinase activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0048660	biological_process	regulation of smooth muscle cell proliferation
B	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
B	0070418	cellular_component	DNA-dependent protein kinase complex
B	0070419	cellular_component	nonhomologous end joining complex
B	0071475	biological_process	cellular hyperosmotic salinity response
B	0071480	biological_process	cellular response to gamma radiation
B	0071481	biological_process	cellular response to X-ray
B	0097110	molecular_function	scaffold protein binding
B	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000723	biological_process	telomere maintenance
C	0000725	biological_process	recombinational repair
C	0000781	cellular_component	chromosome, telomeric region
C	0000783	cellular_component	nuclear telomere cap complex
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0002218	biological_process	activation of innate immune response
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0003684	molecular_function	damaged DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0003691	molecular_function	double-stranded telomeric DNA binding
C	0003723	molecular_function	RNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
C	0006281	biological_process	DNA repair
C	0006302	biological_process	double-strand break repair
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0006310	biological_process	DNA recombination
C	0006974	biological_process	DNA damage response
C	0008047	molecular_function	enzyme activator activity
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0009410	biological_process	response to xenobiotic stimulus
C	0010558	biological_process	negative regulation of macromolecule biosynthetic process
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0022008	biological_process	neurogenesis
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032040	cellular_component	small-subunit processome
C	0032204	biological_process	regulation of telomere maintenance
C	0032212	biological_process	positive regulation of telomere maintenance via telomerase
C	0032508	biological_process	DNA duplex unwinding
C	0032991	cellular_component	protein-containing complex
C	0032993	cellular_component	protein-DNA complex
C	0034462	biological_process	small-subunit processome assembly
C	0034511	molecular_function	U3 snoRNA binding
C	0034774	cellular_component	secretory granule lumen
C	0042162	molecular_function	telomeric DNA binding
C	0042254	biological_process	ribosome biogenesis
C	0043085	biological_process	positive regulation of catalytic activity
C	0043564	cellular_component	Ku70:Ku80 complex
C	0044877	molecular_function	protein-containing complex binding
C	0045027	molecular_function	DNA end binding
C	0045087	biological_process	innate immune response
C	0045860	biological_process	positive regulation of protein kinase activity
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0048660	biological_process	regulation of smooth muscle cell proliferation
C	0050769	biological_process	positive regulation of neurogenesis
C	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
C	0051973	biological_process	positive regulation of telomerase activity
C	0060218	biological_process	hematopoietic stem cell differentiation
C	0070198	biological_process	protein localization to chromosome, telomeric region
C	0070418	cellular_component	DNA-dependent protein kinase complex
C	0070419	cellular_component	nonhomologous end joining complex
C	0071398	biological_process	cellular response to fatty acid
C	0071425	biological_process	hematopoietic stem cell proliferation
C	0071475	biological_process	cellular hyperosmotic salinity response
C	0071480	biological_process	cellular response to gamma radiation
C	0071481	biological_process	cellular response to X-ray
C	0090734	cellular_component	site of DNA damage
C	1904430	biological_process	negative regulation of t-circle formation
C	1990830	biological_process	cellular response to leukemia inhibitory factor
C	1990904	cellular_component	ribonucleoprotein complex
F	0000460	biological_process	maturation of 5.8S rRNA
F	0000723	biological_process	telomere maintenance
F	0000781	cellular_component	chromosome, telomeric region
F	0000785	cellular_component	chromatin
F	0001756	biological_process	somitogenesis
F	0001933	biological_process	negative regulation of protein phosphorylation
F	0002218	biological_process	activation of innate immune response
F	0002326	biological_process	B cell lineage commitment
F	0002327	biological_process	immature B cell differentiation
F	0002328	biological_process	pro-B cell differentiation
F	0002360	biological_process	T cell lineage commitment
F	0003677	molecular_function	DNA binding
F	0003690	molecular_function	double-stranded DNA binding
F	0003723	molecular_function	RNA binding
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004677	molecular_function	DNA-dependent protein kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005667	cellular_component	transcription regulator complex
F	0005730	cellular_component	nucleolus
F	0005829	cellular_component	cytosol
F	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
F	0006281	biological_process	DNA repair
F	0006302	biological_process	double-strand break repair
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006310	biological_process	DNA recombination
F	0006338	biological_process	chromatin remodeling
F	0006468	biological_process	protein phosphorylation
F	0006974	biological_process	DNA damage response
F	0007420	biological_process	brain development
F	0007507	biological_process	heart development
F	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
F	0010212	biological_process	response to ionizing radiation
F	0010332	biological_process	response to gamma radiation
F	0016020	cellular_component	membrane
F	0016233	biological_process	telomere capping
F	0016301	molecular_function	kinase activity
F	0018105	biological_process	peptidyl-serine phosphorylation
F	0018107	biological_process	peptidyl-threonine phosphorylation
F	0019899	molecular_function	enzyme binding
F	0019904	molecular_function	protein domain specific binding
F	0030098	biological_process	lymphocyte differentiation
F	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
F	0031648	biological_process	protein destabilization
F	0032040	cellular_component	small-subunit processome
F	0032869	biological_process	cellular response to insulin stimulus
F	0032991	cellular_component	protein-containing complex
F	0032993	cellular_component	protein-DNA complex
F	0033077	biological_process	T cell differentiation in thymus
F	0033151	biological_process	V(D)J recombination
F	0033152	biological_process	immunoglobulin V(D)J recombination
F	0033153	biological_process	T cell receptor V(D)J recombination
F	0034462	biological_process	small-subunit processome assembly
F	0034511	molecular_function	U3 snoRNA binding
F	0035234	biological_process	ectopic germ cell programmed cell death
F	0035979	molecular_function	histone H2AXS139 kinase activity
F	0036211	biological_process	protein modification process
F	0042254	biological_process	ribosome biogenesis
F	0042752	biological_process	regulation of circadian rhythm
F	0043065	biological_process	positive regulation of apoptotic process
F	0043066	biological_process	negative regulation of apoptotic process
F	0045087	biological_process	innate immune response
F	0045621	biological_process	positive regulation of lymphocyte differentiation
F	0045648	biological_process	positive regulation of erythrocyte differentiation
F	0045727	biological_process	positive regulation of translation
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0048511	biological_process	rhythmic process
F	0048660	biological_process	regulation of smooth muscle cell proliferation
F	0050678	biological_process	regulation of epithelial cell proliferation
F	0060255	biological_process	regulation of macromolecule metabolic process
F	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
F	0070418	cellular_component	DNA-dependent protein kinase complex
F	0070419	cellular_component	nonhomologous end joining complex
F	0080090	biological_process	regulation of primary metabolic process
F	0080135	biological_process	regulation of cellular response to stress
F	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
F	0106310	molecular_function	protein serine kinase activity
F	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
F	1902036	biological_process	regulation of hematopoietic stem cell differentiation
F	1905221	biological_process	positive regulation of platelet formation
F	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
G	0000723	biological_process	telomere maintenance
G	0000725	biological_process	recombinational repair
G	0000781	cellular_component	chromosome, telomeric region
G	0000783	cellular_component	nuclear telomere cap complex
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0002218	biological_process	activation of innate immune response
G	0003677	molecular_function	DNA binding
G	0003678	molecular_function	DNA helicase activity
G	0003684	molecular_function	damaged DNA binding
G	0003690	molecular_function	double-stranded DNA binding
G	0003691	molecular_function	double-stranded telomeric DNA binding
G	0003723	molecular_function	RNA binding
G	0004386	molecular_function	helicase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005667	cellular_component	transcription regulator complex
G	0005694	cellular_component	chromosome
G	0005730	cellular_component	nucleolus
G	0005829	cellular_component	cytosol
G	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
G	0006266	biological_process	DNA ligation
G	0006281	biological_process	DNA repair
G	0006303	biological_process	double-strand break repair via nonhomologous end joining
G	0006310	biological_process	DNA recombination
G	0008094	molecular_function	ATP-dependent activity, acting on DNA
G	0010558	biological_process	negative regulation of macromolecule biosynthetic process
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0016829	molecular_function	lyase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0030332	molecular_function	cyclin binding
G	0032508	biological_process	DNA duplex unwinding
G	0032991	cellular_component	protein-containing complex
G	0032993	cellular_component	protein-DNA complex
G	0034774	cellular_component	secretory granule lumen
G	0042162	molecular_function	telomeric DNA binding
G	0043564	cellular_component	Ku70:Ku80 complex
G	0044877	molecular_function	protein-containing complex binding
G	0045027	molecular_function	DNA end binding
G	0045087	biological_process	innate immune response
G	0045621	biological_process	positive regulation of lymphocyte differentiation
G	0045860	biological_process	positive regulation of protein kinase activity
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0048660	biological_process	regulation of smooth muscle cell proliferation
G	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
G	0070418	cellular_component	DNA-dependent protein kinase complex
G	0070419	cellular_component	nonhomologous end joining complex
G	0071475	biological_process	cellular hyperosmotic salinity response
G	0071480	biological_process	cellular response to gamma radiation
G	0071481	biological_process	cellular response to X-ray
G	0097110	molecular_function	scaffold protein binding
G	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0000723	biological_process	telomere maintenance
H	0000725	biological_process	recombinational repair
H	0000781	cellular_component	chromosome, telomeric region
H	0000783	cellular_component	nuclear telomere cap complex
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0002218	biological_process	activation of innate immune response
H	0003677	molecular_function	DNA binding
H	0003678	molecular_function	DNA helicase activity
H	0003684	molecular_function	damaged DNA binding
H	0003690	molecular_function	double-stranded DNA binding
H	0003691	molecular_function	double-stranded telomeric DNA binding
H	0003723	molecular_function	RNA binding
H	0004386	molecular_function	helicase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005730	cellular_component	nucleolus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
H	0006281	biological_process	DNA repair
H	0006302	biological_process	double-strand break repair
H	0006303	biological_process	double-strand break repair via nonhomologous end joining
H	0006310	biological_process	DNA recombination
H	0006974	biological_process	DNA damage response
H	0008047	molecular_function	enzyme activator activity
H	0008094	molecular_function	ATP-dependent activity, acting on DNA
H	0009410	biological_process	response to xenobiotic stimulus
H	0010558	biological_process	negative regulation of macromolecule biosynthetic process
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0022008	biological_process	neurogenesis
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032040	cellular_component	small-subunit processome
H	0032204	biological_process	regulation of telomere maintenance
H	0032212	biological_process	positive regulation of telomere maintenance via telomerase
H	0032508	biological_process	DNA duplex unwinding
H	0032991	cellular_component	protein-containing complex
H	0032993	cellular_component	protein-DNA complex
H	0034462	biological_process	small-subunit processome assembly
H	0034511	molecular_function	U3 snoRNA binding
H	0034774	cellular_component	secretory granule lumen
H	0042162	molecular_function	telomeric DNA binding
H	0042254	biological_process	ribosome biogenesis
H	0043085	biological_process	positive regulation of catalytic activity
H	0043564	cellular_component	Ku70:Ku80 complex
H	0044877	molecular_function	protein-containing complex binding
H	0045027	molecular_function	DNA end binding
H	0045087	biological_process	innate immune response
H	0045860	biological_process	positive regulation of protein kinase activity
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0048660	biological_process	regulation of smooth muscle cell proliferation
H	0050769	biological_process	positive regulation of neurogenesis
H	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
H	0051973	biological_process	positive regulation of telomerase activity
H	0060218	biological_process	hematopoietic stem cell differentiation
H	0070198	biological_process	protein localization to chromosome, telomeric region
H	0070418	cellular_component	DNA-dependent protein kinase complex
H	0070419	cellular_component	nonhomologous end joining complex
H	0071398	biological_process	cellular response to fatty acid
H	0071425	biological_process	hematopoietic stem cell proliferation
H	0071475	biological_process	cellular hyperosmotic salinity response
H	0071480	biological_process	cellular response to gamma radiation
H	0071481	biological_process	cellular response to X-ray
H	0090734	cellular_component	site of DNA damage
H	1904430	biological_process	negative regulation of t-circle formation
H	1990830	biological_process	cellular response to leukemia inhibitory factor
H	1990904	cellular_component	ribonucleoprotein complex
K	0000793	cellular_component	condensed chromosome
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
K	0006281	biological_process	DNA repair
K	0006302	biological_process	double-strand break repair
K	0006303	biological_process	double-strand break repair via nonhomologous end joining
K	0006310	biological_process	DNA recombination
K	0010165	biological_process	response to X-ray
K	0016874	molecular_function	ligase activity
K	0032807	cellular_component	DNA ligase IV complex
K	0033152	biological_process	immunoglobulin V(D)J recombination
K	0035861	cellular_component	site of double-strand break
K	0042802	molecular_function	identical protein binding
K	0051103	biological_process	DNA ligation involved in DNA repair
K	0051351	biological_process	positive regulation of ligase activity
K	0070419	cellular_component	nonhomologous end joining complex
K	0070975	molecular_function	FHA domain binding
K	0071285	biological_process	cellular response to lithium ion
K	1990166	biological_process	protein localization to site of double-strand break
L	0000793	cellular_component	condensed chromosome
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
L	0006281	biological_process	DNA repair
L	0006302	biological_process	double-strand break repair
L	0006303	biological_process	double-strand break repair via nonhomologous end joining
L	0006310	biological_process	DNA recombination
L	0010165	biological_process	response to X-ray
L	0016874	molecular_function	ligase activity
L	0032807	cellular_component	DNA ligase IV complex
L	0033152	biological_process	immunoglobulin V(D)J recombination
L	0035861	cellular_component	site of double-strand break
L	0042802	molecular_function	identical protein binding
L	0051103	biological_process	DNA ligation involved in DNA repair
L	0051351	biological_process	positive regulation of ligase activity
L	0070419	cellular_component	nonhomologous end joining complex
L	0070975	molecular_function	FHA domain binding
L	0071285	biological_process	cellular response to lithium ion
L	1990166	biological_process	protein localization to site of double-strand break
M	0000012	biological_process	single strand break repair
M	0000287	molecular_function	magnesium ion binding
M	0000781	cellular_component	chromosome, telomeric region
M	0000793	cellular_component	condensed chromosome
M	0001701	biological_process	in utero embryonic development
M	0002328	biological_process	pro-B cell differentiation
M	0003677	molecular_function	DNA binding
M	0003909	molecular_function	DNA ligase activity
M	0003910	molecular_function	DNA ligase (ATP) activity
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
M	0006266	biological_process	DNA ligation
M	0006281	biological_process	DNA repair
M	0006297	biological_process	nucleotide-excision repair, DNA gap filling
M	0006302	biological_process	double-strand break repair
M	0006303	biological_process	double-strand break repair via nonhomologous end joining
M	0006310	biological_process	DNA recombination
M	0007417	biological_process	central nervous system development
M	0008283	biological_process	cell population proliferation
M	0010165	biological_process	response to X-ray
M	0010212	biological_process	response to ionizing radiation
M	0010332	biological_process	response to gamma radiation
M	0016874	molecular_function	ligase activity
M	0022008	biological_process	neurogenesis
M	0032807	cellular_component	DNA ligase IV complex
M	0033077	biological_process	T cell differentiation in thymus
M	0033151	biological_process	V(D)J recombination
M	0033152	biological_process	immunoglobulin V(D)J recombination
M	0033153	biological_process	T cell receptor V(D)J recombination
M	0035019	biological_process	somatic stem cell population maintenance
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0043524	biological_process	negative regulation of neuron apoptotic process
M	0045190	biological_process	isotype switching
M	0046872	molecular_function	metal ion binding
M	0048144	biological_process	fibroblast proliferation
M	0048146	biological_process	positive regulation of fibroblast proliferation
M	0050769	biological_process	positive regulation of neurogenesis
M	0051102	biological_process	DNA ligation involved in DNA recombination
M	0051103	biological_process	DNA ligation involved in DNA repair
M	0051276	biological_process	chromosome organization
M	0051301	biological_process	cell division
M	0051402	biological_process	neuron apoptotic process
M	0070419	cellular_component	nonhomologous end joining complex
M	0071285	biological_process	cellular response to lithium ion
M	0071479	biological_process	cellular response to ionizing radiation
M	0071897	biological_process	DNA biosynthetic process
M	0072089	biological_process	stem cell proliferation
M	0075713	biological_process	establishment of integrated proviral latency
M	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
M	1904155	biological_process	DN2 thymocyte differentiation
M	2001252	biological_process	positive regulation of chromosome organization
N	0000793	cellular_component	condensed chromosome
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
N	0006281	biological_process	DNA repair
N	0006302	biological_process	double-strand break repair
N	0006303	biological_process	double-strand break repair via nonhomologous end joining
N	0006310	biological_process	DNA recombination
N	0010165	biological_process	response to X-ray
N	0016874	molecular_function	ligase activity
N	0032807	cellular_component	DNA ligase IV complex
N	0033152	biological_process	immunoglobulin V(D)J recombination
N	0035861	cellular_component	site of double-strand break
N	0042802	molecular_function	identical protein binding
N	0051103	biological_process	DNA ligation involved in DNA repair
N	0051351	biological_process	positive regulation of ligase activity
N	0070419	cellular_component	nonhomologous end joining complex
N	0070975	molecular_function	FHA domain binding
N	0071285	biological_process	cellular response to lithium ion
N	1990166	biological_process	protein localization to site of double-strand break
O	0000793	cellular_component	condensed chromosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
O	0006281	biological_process	DNA repair
O	0006302	biological_process	double-strand break repair
O	0006303	biological_process	double-strand break repair via nonhomologous end joining
O	0006310	biological_process	DNA recombination
O	0010165	biological_process	response to X-ray
O	0016874	molecular_function	ligase activity
O	0032807	cellular_component	DNA ligase IV complex
O	0033152	biological_process	immunoglobulin V(D)J recombination
O	0035861	cellular_component	site of double-strand break
O	0042802	molecular_function	identical protein binding
O	0051103	biological_process	DNA ligation involved in DNA repair
O	0051351	biological_process	positive regulation of ligase activity
O	0070419	cellular_component	nonhomologous end joining complex
O	0070975	molecular_function	FHA domain binding
O	0071285	biological_process	cellular response to lithium ion
O	1990166	biological_process	protein localization to site of double-strand break
P	0000012	biological_process	single strand break repair
P	0000287	molecular_function	magnesium ion binding
P	0000781	cellular_component	chromosome, telomeric region
P	0000793	cellular_component	condensed chromosome
P	0001701	biological_process	in utero embryonic development
P	0002328	biological_process	pro-B cell differentiation
P	0003677	molecular_function	DNA binding
P	0003909	molecular_function	DNA ligase activity
P	0003910	molecular_function	DNA ligase (ATP) activity
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
P	0006266	biological_process	DNA ligation
P	0006281	biological_process	DNA repair
P	0006297	biological_process	nucleotide-excision repair, DNA gap filling
P	0006302	biological_process	double-strand break repair
P	0006303	biological_process	double-strand break repair via nonhomologous end joining
P	0006310	biological_process	DNA recombination
P	0007417	biological_process	central nervous system development
P	0008283	biological_process	cell population proliferation
P	0010165	biological_process	response to X-ray
P	0010212	biological_process	response to ionizing radiation
P	0010332	biological_process	response to gamma radiation
P	0016874	molecular_function	ligase activity
P	0022008	biological_process	neurogenesis
P	0032807	cellular_component	DNA ligase IV complex
P	0033077	biological_process	T cell differentiation in thymus
P	0033151	biological_process	V(D)J recombination
P	0033152	biological_process	immunoglobulin V(D)J recombination
P	0033153	biological_process	T cell receptor V(D)J recombination
P	0035019	biological_process	somatic stem cell population maintenance
P	0043231	cellular_component	intracellular membrane-bounded organelle
P	0043524	biological_process	negative regulation of neuron apoptotic process
P	0045190	biological_process	isotype switching
P	0046872	molecular_function	metal ion binding
P	0048144	biological_process	fibroblast proliferation
P	0048146	biological_process	positive regulation of fibroblast proliferation
P	0050769	biological_process	positive regulation of neurogenesis
P	0051102	biological_process	DNA ligation involved in DNA recombination
P	0051103	biological_process	DNA ligation involved in DNA repair
P	0051276	biological_process	chromosome organization
P	0051301	biological_process	cell division
P	0051402	biological_process	neuron apoptotic process
P	0070419	cellular_component	nonhomologous end joining complex
P	0071285	biological_process	cellular response to lithium ion
P	0071479	biological_process	cellular response to ionizing radiation
P	0071897	biological_process	DNA biosynthetic process
P	0072089	biological_process	stem cell proliferation
P	0075713	biological_process	establishment of integrated proviral latency
P	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
P	1904155	biological_process	DN2 thymocyte differentiation
P	2001252	biological_process	positive regulation of chromosome organization
Q	0001650	cellular_component	fibrillar center
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005694	cellular_component	chromosome
Q	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
Q	0006281	biological_process	DNA repair
Q	0006302	biological_process	double-strand break repair
Q	0006303	biological_process	double-strand break repair via nonhomologous end joining
Q	0007417	biological_process	central nervous system development
Q	0010212	biological_process	response to ionizing radiation
Q	0030183	biological_process	B cell differentiation
Q	0030217	biological_process	T cell differentiation
Q	0032807	cellular_component	DNA ligase IV complex
Q	0033152	biological_process	immunoglobulin V(D)J recombination
Q	0035861	cellular_component	site of double-strand break
Q	0045027	molecular_function	DNA end binding
Q	0051103	biological_process	DNA ligation involved in DNA repair
Q	0051351	biological_process	positive regulation of ligase activity
Q	0070182	molecular_function	DNA polymerase binding
Q	0070419	cellular_component	nonhomologous end joining complex
R	0001650	cellular_component	fibrillar center
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
R	0006281	biological_process	DNA repair
R	0006302	biological_process	double-strand break repair
R	0006303	biological_process	double-strand break repair via nonhomologous end joining
R	0007417	biological_process	central nervous system development
R	0010212	biological_process	response to ionizing radiation
R	0030183	biological_process	B cell differentiation
R	0030217	biological_process	T cell differentiation
R	0032807	cellular_component	DNA ligase IV complex
R	0033152	biological_process	immunoglobulin V(D)J recombination
R	0035861	cellular_component	site of double-strand break
R	0045027	molecular_function	DNA end binding
R	0051103	biological_process	DNA ligation involved in DNA repair
R	0051351	biological_process	positive regulation of ligase activity
R	0070182	molecular_function	DNA polymerase binding
R	0070419	cellular_component	nonhomologous end joining complex
S	0000460	biological_process	maturation of 5.8S rRNA
S	0000723	biological_process	telomere maintenance
S	0000781	cellular_component	chromosome, telomeric region
S	0000785	cellular_component	chromatin
S	0001756	biological_process	somitogenesis
S	0001933	biological_process	negative regulation of protein phosphorylation
S	0002218	biological_process	activation of innate immune response
S	0002326	biological_process	B cell lineage commitment
S	0002327	biological_process	immature B cell differentiation
S	0002328	biological_process	pro-B cell differentiation
S	0002360	biological_process	T cell lineage commitment
S	0003677	molecular_function	DNA binding
S	0003690	molecular_function	double-stranded DNA binding
S	0003723	molecular_function	RNA binding
S	0004672	molecular_function	protein kinase activity
S	0004674	molecular_function	protein serine/threonine kinase activity
S	0004677	molecular_function	DNA-dependent protein kinase activity
S	0005515	molecular_function	protein binding
S	0005524	molecular_function	ATP binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005667	cellular_component	transcription regulator complex
S	0005730	cellular_component	nucleolus
S	0005829	cellular_component	cytosol
S	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
S	0006281	biological_process	DNA repair
S	0006302	biological_process	double-strand break repair
S	0006303	biological_process	double-strand break repair via nonhomologous end joining
S	0006310	biological_process	DNA recombination
S	0006338	biological_process	chromatin remodeling
S	0006468	biological_process	protein phosphorylation
S	0006974	biological_process	DNA damage response
S	0007420	biological_process	brain development
S	0007507	biological_process	heart development
S	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
S	0010212	biological_process	response to ionizing radiation
S	0010332	biological_process	response to gamma radiation
S	0016020	cellular_component	membrane
S	0016233	biological_process	telomere capping
S	0016301	molecular_function	kinase activity
S	0018105	biological_process	peptidyl-serine phosphorylation
S	0018107	biological_process	peptidyl-threonine phosphorylation
S	0019899	molecular_function	enzyme binding
S	0019904	molecular_function	protein domain specific binding
S	0030098	biological_process	lymphocyte differentiation
S	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
S	0031648	biological_process	protein destabilization
S	0032040	cellular_component	small-subunit processome
S	0032869	biological_process	cellular response to insulin stimulus
S	0032991	cellular_component	protein-containing complex
S	0032993	cellular_component	protein-DNA complex
S	0033077	biological_process	T cell differentiation in thymus
S	0033151	biological_process	V(D)J recombination
S	0033152	biological_process	immunoglobulin V(D)J recombination
S	0033153	biological_process	T cell receptor V(D)J recombination
S	0034462	biological_process	small-subunit processome assembly
S	0034511	molecular_function	U3 snoRNA binding
S	0035234	biological_process	ectopic germ cell programmed cell death
S	0035979	molecular_function	histone H2AXS139 kinase activity
S	0036211	biological_process	protein modification process
S	0042254	biological_process	ribosome biogenesis
S	0042752	biological_process	regulation of circadian rhythm
S	0043065	biological_process	positive regulation of apoptotic process
S	0043066	biological_process	negative regulation of apoptotic process
S	0045087	biological_process	innate immune response
S	0045621	biological_process	positive regulation of lymphocyte differentiation
S	0045648	biological_process	positive regulation of erythrocyte differentiation
S	0045727	biological_process	positive regulation of translation
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	0048511	biological_process	rhythmic process
S	0048660	biological_process	regulation of smooth muscle cell proliferation
S	0050678	biological_process	regulation of epithelial cell proliferation
S	0060255	biological_process	regulation of macromolecule metabolic process
S	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
S	0070418	cellular_component	DNA-dependent protein kinase complex
S	0070419	cellular_component	nonhomologous end joining complex
S	0080090	biological_process	regulation of primary metabolic process
S	0080135	biological_process	regulation of cellular response to stress
S	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
S	0106310	molecular_function	protein serine kinase activity
S	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
S	1902036	biological_process	regulation of hematopoietic stem cell differentiation
S	1905221	biological_process	positive regulation of platelet formation
S	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
T	0000723	biological_process	telomere maintenance
T	0000725	biological_process	recombinational repair
T	0000781	cellular_component	chromosome, telomeric region
T	0000783	cellular_component	nuclear telomere cap complex
T	0000976	molecular_function	transcription cis-regulatory region binding
T	0002218	biological_process	activation of innate immune response
T	0003677	molecular_function	DNA binding
T	0003678	molecular_function	DNA helicase activity
T	0003684	molecular_function	damaged DNA binding
T	0003690	molecular_function	double-stranded DNA binding
T	0003691	molecular_function	double-stranded telomeric DNA binding
T	0003723	molecular_function	RNA binding
T	0004386	molecular_function	helicase activity
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005576	cellular_component	extracellular region
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005667	cellular_component	transcription regulator complex
T	0005694	cellular_component	chromosome
T	0005730	cellular_component	nucleolus
T	0005829	cellular_component	cytosol
T	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
T	0006266	biological_process	DNA ligation
T	0006281	biological_process	DNA repair
T	0006303	biological_process	double-strand break repair via nonhomologous end joining
T	0006310	biological_process	DNA recombination
T	0008094	molecular_function	ATP-dependent activity, acting on DNA
T	0010558	biological_process	negative regulation of macromolecule biosynthetic process
T	0016020	cellular_component	membrane
T	0016787	molecular_function	hydrolase activity
T	0016829	molecular_function	lyase activity
T	0016887	molecular_function	ATP hydrolysis activity
T	0030332	molecular_function	cyclin binding
T	0032508	biological_process	DNA duplex unwinding
T	0032991	cellular_component	protein-containing complex
T	0032993	cellular_component	protein-DNA complex
T	0034774	cellular_component	secretory granule lumen
T	0042162	molecular_function	telomeric DNA binding
T	0043564	cellular_component	Ku70:Ku80 complex
T	0044877	molecular_function	protein-containing complex binding
T	0045027	molecular_function	DNA end binding
T	0045087	biological_process	innate immune response
T	0045621	biological_process	positive regulation of lymphocyte differentiation
T	0045860	biological_process	positive regulation of protein kinase activity
T	0045892	biological_process	negative regulation of DNA-templated transcription
T	0045893	biological_process	positive regulation of DNA-templated transcription
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
T	0048660	biological_process	regulation of smooth muscle cell proliferation
T	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
T	0070418	cellular_component	DNA-dependent protein kinase complex
T	0070419	cellular_component	nonhomologous end joining complex
T	0071475	biological_process	cellular hyperosmotic salinity response
T	0071480	biological_process	cellular response to gamma radiation
T	0071481	biological_process	cellular response to X-ray
T	0097110	molecular_function	scaffold protein binding
T	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
T	1904813	cellular_component	ficolin-1-rich granule lumen
U	0000723	biological_process	telomere maintenance
U	0000725	biological_process	recombinational repair
U	0000781	cellular_component	chromosome, telomeric region
U	0000783	cellular_component	nuclear telomere cap complex
U	0000976	molecular_function	transcription cis-regulatory region binding
U	0002218	biological_process	activation of innate immune response
U	0003677	molecular_function	DNA binding
U	0003678	molecular_function	DNA helicase activity
U	0003684	molecular_function	damaged DNA binding
U	0003690	molecular_function	double-stranded DNA binding
U	0003691	molecular_function	double-stranded telomeric DNA binding
U	0003723	molecular_function	RNA binding
U	0004386	molecular_function	helicase activity
U	0005515	molecular_function	protein binding
U	0005524	molecular_function	ATP binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005694	cellular_component	chromosome
U	0005730	cellular_component	nucleolus
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005886	cellular_component	plasma membrane
U	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
U	0006281	biological_process	DNA repair
U	0006302	biological_process	double-strand break repair
U	0006303	biological_process	double-strand break repair via nonhomologous end joining
U	0006310	biological_process	DNA recombination
U	0006974	biological_process	DNA damage response
U	0008047	molecular_function	enzyme activator activity
U	0008094	molecular_function	ATP-dependent activity, acting on DNA
U	0009410	biological_process	response to xenobiotic stimulus
U	0010558	biological_process	negative regulation of macromolecule biosynthetic process
U	0016020	cellular_component	membrane
U	0016787	molecular_function	hydrolase activity
U	0016887	molecular_function	ATP hydrolysis activity
U	0022008	biological_process	neurogenesis
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0032040	cellular_component	small-subunit processome
U	0032204	biological_process	regulation of telomere maintenance
U	0032212	biological_process	positive regulation of telomere maintenance via telomerase
U	0032508	biological_process	DNA duplex unwinding
U	0032991	cellular_component	protein-containing complex
U	0032993	cellular_component	protein-DNA complex
U	0034462	biological_process	small-subunit processome assembly
U	0034511	molecular_function	U3 snoRNA binding
U	0034774	cellular_component	secretory granule lumen
U	0042162	molecular_function	telomeric DNA binding
U	0042254	biological_process	ribosome biogenesis
U	0043085	biological_process	positive regulation of catalytic activity
U	0043564	cellular_component	Ku70:Ku80 complex
U	0044877	molecular_function	protein-containing complex binding
U	0045027	molecular_function	DNA end binding
U	0045087	biological_process	innate immune response
U	0045860	biological_process	positive regulation of protein kinase activity
U	0045892	biological_process	negative regulation of DNA-templated transcription
U	0048660	biological_process	regulation of smooth muscle cell proliferation
U	0050769	biological_process	positive regulation of neurogenesis
U	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
U	0051973	biological_process	positive regulation of telomerase activity
U	0060218	biological_process	hematopoietic stem cell differentiation
U	0070198	biological_process	protein localization to chromosome, telomeric region
U	0070418	cellular_component	DNA-dependent protein kinase complex
U	0070419	cellular_component	nonhomologous end joining complex
U	0071398	biological_process	cellular response to fatty acid
U	0071425	biological_process	hematopoietic stem cell proliferation
U	0071475	biological_process	cellular hyperosmotic salinity response
U	0071480	biological_process	cellular response to gamma radiation
U	0071481	biological_process	cellular response to X-ray
U	0090734	cellular_component	site of DNA damage
U	1904430	biological_process	negative regulation of t-circle formation
U	1990830	biological_process	cellular response to leukemia inhibitory factor
U	1990904	cellular_component	ribonucleoprotein complex
X	0001650	cellular_component	fibrillar center
X	0003677	molecular_function	DNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005694	cellular_component	chromosome
X	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
X	0006281	biological_process	DNA repair
X	0006302	biological_process	double-strand break repair
X	0006303	biological_process	double-strand break repair via nonhomologous end joining
X	0007417	biological_process	central nervous system development
X	0010212	biological_process	response to ionizing radiation
X	0030183	biological_process	B cell differentiation
X	0030217	biological_process	T cell differentiation
X	0032807	cellular_component	DNA ligase IV complex
X	0033152	biological_process	immunoglobulin V(D)J recombination
X	0035861	cellular_component	site of double-strand break
X	0045027	molecular_function	DNA end binding
X	0051103	biological_process	DNA ligation involved in DNA repair
X	0051351	biological_process	positive regulation of ligase activity
X	0070182	molecular_function	DNA polymerase binding
X	0070419	cellular_component	nonhomologous end joining complex
Y	0001650	cellular_component	fibrillar center
Y	0003677	molecular_function	DNA binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005694	cellular_component	chromosome
Y	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
Y	0006281	biological_process	DNA repair
Y	0006302	biological_process	double-strand break repair
Y	0006303	biological_process	double-strand break repair via nonhomologous end joining
Y	0007417	biological_process	central nervous system development
Y	0010212	biological_process	response to ionizing radiation
Y	0030183	biological_process	B cell differentiation
Y	0030217	biological_process	T cell differentiation
Y	0032807	cellular_component	DNA ligase IV complex
Y	0033152	biological_process	immunoglobulin V(D)J recombination
Y	0035861	cellular_component	site of double-strand break
Y	0045027	molecular_function	DNA end binding
Y	0051103	biological_process	DNA ligation involved in DNA repair
Y	0051351	biological_process	positive regulation of ligase activity
Y	0070182	molecular_function	DNA polymerase binding
Y	0070419	cellular_component	nonhomologous end joining complex

Functional Information from PROSITE/UniProt

site_id	PS00333
Number of Residues	25
Details	DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGIMVKqplsi...YKpdk...RgegwlKIK

Chain	Residue	Details
M	GLU427-LYS451

---

site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. ETKLDGERM

Chain	Residue	Details
M	GLU271-MET279

---

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgg.EDLRQDqrveQ

Chain	Residue	Details
F	VAL3752-GLN3766

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ShAlicIshWILgIgDRHlnN

Chain	Residue	Details
F	SER3907-ASN3927

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
H	LYS144
C	LYS665
U	LYS144
U	LYS265
U	LYS332
U	LYS660
U	LYS665
H	LYS265
H	LYS332
H	LYS660
H	LYS665
C	LYS144
C	LYS265
C	LYS332
C	LYS660

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
H	SER255
T	SER27
T	SER306
T	SER560
A	LYS1209
A	LYS1970
A	LYS2259
A	LYS3241
A	LYS3260
A	LYS3621
A	LYS3638
H	SER258
A	LYS3642
S	LYS117
S	LYS828
S	LYS1209
S	LYS1970
S	LYS2259
S	LYS3241
S	LYS3260
S	LYS3621
S	LYS3638
H	SER318
S	LYS3642
C	SER255
C	SER258
C	SER318
U	SER255
U	SER258
U	SER318

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
H	THR535
A	SER841
A	SER1065
A	SER2789
A	SER3731
A	SER3821
S	SER511
S	SER687
S	SER841
S	SER1065
S	SER2789
C	THR535
S	SER3731
S	SER3821
U	THR535
F	SER1065
F	SER2789
F	SER3731
F	SER3821
A	SER511
A	SER687

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:10026262, ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	SER577
T	LYS331
T	LYS338
T	LYS461
C	SER577
U	SER577
G	LYS461
B	LYS31
B	LYS331
B	LYS338
B	LYS461
T	LYS31

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000305|PubMed:10026262

Chain	Residue	Details
H	SER579
C	SER579
U	SER579
Y	SER287

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:10026262

Chain	Residue	Details
H	SER580
C	SER580
U	SER580
O	THR233

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: Phosphothreonine; by PRKDC => ECO:0000305|PubMed:10026262

Chain	Residue	Details
H	THR715
C	THR715
U	THR715
O	SER237

---

site_id	SWS_FT_FI8
Number of Residues	21
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
H	LYS195
C	LYS532
C	LYS534
C	LYS566
C	LYS669
C	LYS688
U	LYS195
U	LYS532
U	LYS534
U	LYS566
B	SER520
U	LYS669
U	LYS688
H	LYS532
H	LYS534
H	LYS566
H	LYS669
H	LYS688
C	LYS195

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:28112733

Chain	Residue	Details
H	LYS568
C	LYS568
U	LYS568
A	THR2647
S	THR2638
S	THR2647

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
G	LYS287
G	LYS317
B	LYS287
B	LYS317
T	LYS287
T	LYS317

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733

Chain	Residue	Details
F	SER4026
G	LYS556
S	SER4026
B	LYS556
T	LYS556

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:23186163

Chain	Residue	Details
K	SER320
L	SER320
N	SER320
O	SER320

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754

Chain	Residue	Details
K	THR323
L	THR323
N	THR323
O	THR323

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
K	SER327
K	SER328
L	SER327
L	SER328
N	SER327
N	SER328
O	SER327
O	SER328

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:16478998

Chain	Residue	Details
K	LYS210
L	LYS210
N	LYS210
O	LYS210

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26774286

Chain	Residue	Details
K	LYS296
L	LYS296
N	LYS296
O	LYS296

---