8A0Z

Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and pyrimethamine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Dihydrofolate reductase	polymer	204	23634.1	2	UniProt (A0A0L0P1H8) Pfam (PF00186) In PDB	[Candida] auris
2	B, A	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
3	B, A	5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE	non-polymer		248.7	2	Chemie (CP6)
4	B, A	NITRATE ION	non-polymer		62.0	2	Chemie (NO3)
5	B, A	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	2	Chemie (EPE)
6		water	water		18.0	356	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47268.3
Non-Polymers*	Number of molecules	8
	Total formula weight	2588.9
All*	Total formula weight	49857.2

*Water molecules are not included.