8A0Z

Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and pyrimethamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004146	molecular_function	dihydrofolate reductase activity
A	0005739	cellular_component	mitochondrion
A	0046452	biological_process	dihydrofolate metabolic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046655	biological_process	folic acid metabolic process
A	0050661	molecular_function	NADP binding
B	0004146	molecular_function	dihydrofolate reductase activity
B	0005739	cellular_component	mitochondrion
B	0046452	biological_process	dihydrofolate metabolic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046655	biological_process	folic acid metabolic process
B	0050661	molecular_function	NADP binding

Functional Information from PROSITE/UniProt

site_id	PS00075
Number of Residues	23
Details	DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGakgsLPWrlkn.EmkyFkdvT

Chain	Residue	Details
B	GLY18-THR40

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