7ZYH

Crystal structure of human CPSF30 in complex with hFip1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J	Cleavage and polyadenylation specificity factor subunit 4	polymer	64	7482.7	4	UniProt (O95639) Pfam (PF00642) In PDB	Homo sapiens (human)	Cleavage and polyadenylation specificity factor 30 kDa subunit,CPSF 30 kDa subunit,NS1 effector domain-binding protein 1,Neb-1,No arches homolog
2	B, C, E, F, H...	Isoform 4 of Pre-mRNA 3'-end-processing factor FIP1	polymer	69	7865.8	8	UniProt (Q6UN15-4) Pfam (PF05182) UniProt (by SIFTS) (Q6UN15) In PDB	Homo sapiens (human)	hFip1,FIP1-like 1 protein,Factor interacting with PAP,Rearranged in hypereosinophilia
3	A, D, G, J	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
4		water	water		18.0	98	Chemie (HOH)

Sequence modifications

A, D, G, J: 118 - 178 (UniProt: O95639)

PDB	External Database	Details
Ser 115	-	expression tag
Asn 116	-	expression tag
Ala 117	-	expression tag

B, C, E, F, H, I, K, L: 130 - 195 (UniProt: Q6UN15-4)

PDB	External Database	Details
Ser 127	-	expression tag
Asn 128	-	expression tag
Ala 129	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	92856.9
Non-Polymers*	Number of molecules	8
	Total formula weight	523.3
All*	Total formula weight	93380.1

*Water molecules are not included.