7ZRZ
Structure of the human tRNA splicing endonuclease defines substrate recognition
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | AP1 | tRNA-splicing endonuclease subunit Sen34 | polymer | 263 | 28805.8 | 1 | UniProt (Q9BSV6) Pfam (PF01974) In PDB | Homo sapiens (human) | Leukocyte receptor cluster member 5,tRNA-intron endonuclease Sen34,HsSen34 |
2 | BP4 | tRNA-splicing endonuclease subunit Sen2 | polymer | 260 | 30166.0 | 1 | UniProt (Q8NCE0) Pfam (PF02778) Pfam (PF01974) In PDB | Homo sapiens (human) | tRNA-intron endonuclease Sen2,HsSen2 |
3 | CP1 | tRNA-splicing endonuclease subunit Sen54 | polymer | 293 | 32551.7 | 1 | UniProt (Q7Z6J9) Pfam (PF12928) In PDB | Homo sapiens (human) | SEN54 homolog,HsSEN54,tRNA-intron endonuclease Sen54 |
4 | DP1 | tRNA-splicing endonuclease subunit Sen15 | polymer | 217 | 23860.9 | 1 | UniProt (Q8WW01) Pfam (PF09631) In PDB | Homo sapiens (human) | SEN15 homolog,HsSEN15,tRNA-intron endonuclease Sen15 |
5 | ZN1 | pre-tRNA Arg TCT 3-2 | polymer | 89 | 28747.0 | 1 | Homo sapiens |
Sequence modifications
AP1: 1 - 167 (UniProt: Q9BSV6)
AP1: 180 - 310 (UniProt: Q9BSV6)
BP4: 206 - 286 (UniProt: Q8NCE0)
BP4: 292 - 465 (UniProt: Q8NCE0)
CP1: 1 - 411 (UniProt: Q7Z6J9)
CP1: 425 - 526 (UniProt: Q7Z6J9)
DP1: 1 - 171 (UniProt: Q8WW01)
AP1: 180 - 310 (UniProt: Q9BSV6)
PDB | External Database | Details |
---|---|---|
Gly 168 | - | linker |
Gly 169 | - | linker |
Ser 170 | - | linker |
Gly 171 | - | linker |
Gly 172 | - | linker |
Ser 173 | - | linker |
Gly 174 | - | linker |
Gly 175 | - | linker |
Ser 176 | - | linker |
Gly 177 | - | linker |
Gly 178 | - | linker |
Ser 179 | - | linker |
Phe 255 | His 255 | conflict |
BP4: 292 - 465 (UniProt: Q8NCE0)
PDB | External Database | Details |
---|---|---|
Gly 287 | - | linker |
Gly 288 | - | linker |
Ser 289 | - | linker |
Gly 290 | - | linker |
Gly 291 | - | linker |
Phe 377 | His 377 | conflict |
CP1: 425 - 526 (UniProt: Q7Z6J9)
PDB | External Database | Details |
---|---|---|
Gly 412 | - | linker |
Gly 413 | - | linker |
Ser 414 | - | linker |
Gly 415 | - | linker |
Gly 416 | - | linker |
Ser 417 | - | linker |
Gly 418 | - | linker |
Gly 419 | - | linker |
Ser 420 | - | linker |
Gly 421 | - | linker |
Gly 422 | - | linker |
Ser 423 | - | linker |
Gly 424 | - | linker |
PDB | External Database | Details |
---|---|---|
Met -45 | - | initiating methionine |
Asp -44 | - | expression tag |
Glu -43 | - | expression tag |
Lys -42 | - | expression tag |
Thr -41 | - | expression tag |
Thr -40 | - | expression tag |
Gly -39 | - | expression tag |
Trp -38 | - | expression tag |
Arg -37 | - | expression tag |
Gly -36 | - | expression tag |
Gly -35 | - | expression tag |
His -34 | - | expression tag |
Val -33 | - | expression tag |
Val -32 | - | expression tag |
Glu -31 | - | expression tag |
Gly -30 | - | expression tag |
Leu -29 | - | expression tag |
Ala -28 | - | expression tag |
Gly -27 | - | expression tag |
Glu -26 | - | expression tag |
Leu -25 | - | expression tag |
Glu -24 | - | expression tag |
Gln -23 | - | expression tag |
Leu -22 | - | expression tag |
Arg -21 | - | expression tag |
Ala -20 | - | expression tag |
Arg -19 | - | expression tag |
Leu -18 | - | expression tag |
Glu -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
Pro -14 | - | expression tag |
Gln -13 | - | expression tag |
Gly -12 | - | expression tag |
Gln -11 | - | expression tag |
Arg -10 | - | expression tag |
Glu -9 | - | expression tag |
Pro -8 | - | expression tag |
Gly -7 | - | expression tag |
Glu -6 | - | expression tag |
Asn -5 | - | expression tag |
Leu -4 | - | expression tag |
Tyr -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 144131.4 | |
All* | Total formula weight | 144131.4 |