7ZNJ
Structure of an ALYREF-exon junction complex hexamer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, K, P, U... (A, a, F, f, K...) | Eukaryotic initiation factor 4A-III, N-terminally processed | polymer | 382 | 43819.4 | 6 | UniProt (P38919) Pfam (PF00270) Pfam (PF00271) | Homo sapiens (human) | |
| 2 | AA, B, G, L, Q... (B, b, G, g, L...) | Protein mago nashi homolog | polymer | 146 | 17189.6 | 6 | UniProt (P61326) Pfam (PF02792) | Homo sapiens (human) | |
| 3 | BA, C, H, M, R... (C, c, H, h, M...) | RNA-binding protein 8A | polymer | 91 | 10370.5 | 6 | UniProt (Q9Y5S9) Pfam (PF00076) | Homo sapiens (human) | Binder of OVCA1-1,BOV-1,RNA-binding motif protein 8A,RNA-binding protein Y14,Ribonucleoprotein RBM8A |
| 4 | CA, D, I, N, S... (D, d, I, i, N...) | Maltose/maltodextrin-binding periplasmic protein,THO complex subunit 4 | polymer | 527 | 57598.9 | 6 | UniProt (P0AEY0) UniProt (Q86V81) Pfam (PF01547) Pfam (PF00076) | Homo sapiens (human) | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Tho4,Ally of AML-1 and LEF-1,Aly/REF export factor,Transcriptional coactivator Aly/REF,bZIP-enhancing factor BEF |
| 5 | DA, E, J, O, T... (E, e, J, j, O...) | RNA | polymer | 6 | 1792.0 | 6 | Homo sapiens | ||
| 6 | EA, GA, IA, KA, MA... (A, a, F, f, K...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 7 | FA, HA, JA, LA, NA... (A, a, F, f, K...) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 6 | Chemie (ANP) |
Sequence modifications
D, d, I, i, N, n: -330 - 39 (UniProt: P0AEY0)
D, d, I, i, N, n: 56 - 182 (UniProt: Q86V81)
| PDB | External Database | Details |
|---|---|---|
| Met -344 | - | initiating methionine |
| Gln -343 | - | expression tag |
| Leu -342 | - | expression tag |
| Ser -341 | - | expression tag |
| His -340 | - | expression tag |
| His -339 | - | expression tag |
| His -338 | - | expression tag |
| His -337 | - | expression tag |
| His -336 | - | expression tag |
| His -335 | - | expression tag |
| His -334 | - | expression tag |
| His -333 | - | expression tag |
| His -332 | - | expression tag |
| His -331 | - | expression tag |
| Ser -329 | Ala 24 | conflict |
| Gly -328 | Leu 25 | conflict |
| Met -327 | Ala 26 | conflict |
| Ser 40 | - | linker |
| Ser 41 | - | linker |
| Gly 42 | - | linker |
| Leu 43 | - | linker |
| Glu 44 | - | linker |
| Val 45 | - | linker |
| Leu 46 | - | linker |
| Phe 47 | - | linker |
| Gln 48 | - | linker |
| Gly 49 | - | linker |
| Pro 50 | - | linker |
| Gly 51 | - | linker |
| Ser 52 | - | linker |
| Ser 53 | - | linker |
| Gly 54 | - | linker |
| Ile 55 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 30 |
| Total formula weight | 784622.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3183.0 | |
| All* | Total formula weight | 787805.5 |
