7ZNJ

Structure of an ALYREF-exon junction complex hexamer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, a, F, f, K...	Eukaryotic initiation factor 4A-III, N-terminally processed	polymer	382	43819.4	6	UniProt (P38919) Pfam (PF00270) Pfam (PF00271) In PDB	Homo sapiens (human)
2	B, b, G, g, L...	Protein mago nashi homolog	polymer	146	17189.6	6	UniProt (P61326) Pfam (PF02792) In PDB	Homo sapiens (human)
3	C, c, H, h, M...	RNA-binding protein 8A	polymer	91	10370.5	6	UniProt (Q9Y5S9) Pfam (PF00076) In PDB	Homo sapiens (human)	Binder of OVCA1-1,BOV-1,RNA-binding motif protein 8A,RNA-binding protein Y14,Ribonucleoprotein RBM8A
4	D, d, I, i, N...	Maltose/maltodextrin-binding periplasmic protein,THO complex subunit 4	polymer	527	57598.9	6	UniProt (P0AEY0) UniProt (Q86V81) Pfam (PF01547) Pfam (PF00076) In PDB	Homo sapiens (human)	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Tho4,Ally of AML-1 and LEF-1,Aly/REF export factor,Transcriptional coactivator Aly/REF,bZIP-enhancing factor BEF
5	E, e, J, j, O...	RNA	polymer	6	1792.0	6		Homo sapiens
6	A, a, F, f, K...	MAGNESIUM ION	non-polymer		24.3	6	Chemie (MG)
7	A, a, F, f, K...	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	6	Chemie (ANP)

Sequence modifications

D, d, I, i, N, n: -330 - 39 (UniProt: P0AEY0)

PDB	External Database	Details
Met -344	-	initiating methionine
Gln -343	-	expression tag
Leu -342	-	expression tag
Ser -341	-	expression tag
His -340	-	expression tag
His -339	-	expression tag
His -338	-	expression tag
His -337	-	expression tag
His -336	-	expression tag
His -335	-	expression tag
His -334	-	expression tag
His -333	-	expression tag
His -332	-	expression tag
His -331	-	expression tag
Ser -329	Ala 24	conflict
Gly -328	Leu 25	conflict
Met -327	Ala 26	conflict
Ser 40	-	linker
Ser 41	-	linker
Gly 42	-	linker
Leu 43	-	linker
Glu 44	-	linker
Val 45	-	linker
Leu 46	-	linker
Phe 47	-	linker
Gln 48	-	linker
Gly 49	-	linker
Pro 50	-	linker
Gly 51	-	linker
Ser 52	-	linker
Ser 53	-	linker
Gly 54	-	linker
Ile 55	-	linker

D, d, I, i, N, n: 56 - 182 (UniProt: Q86V81)

Contents of the asymmetric unit

Polymers	Number of chains	30
	Total formula weight	784622.5
Non-Polymers*	Number of molecules	12
	Total formula weight	3183.0
All*	Total formula weight	787805.5

*Water molecules are not included.