7Z8B
Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Cullin-7 | polymer | 1700 | 191564.4 | 1 | UniProt (Q14999) Pfam (PF11515) Pfam (PF03256) Pfam (PF00888) | Homo sapiens (human) | CUL-7 |
| 2 | B (F) | F-box/WD repeat-containing protein 8 | polymer | 600 | 67628.9 | 1 | UniProt (Q8N3Y1) Pfam (PF00646) | Homo sapiens (human) | F-box and WD-40 domain-containing protein 8,F-box only protein 29 |
| 3 | C (R) | E3 ubiquitin-protein ligase RBX1 | polymer | 108 | 12290.0 | 1 | UniProt (P62877) Pfam (PF12678) | Homo sapiens (human) | E3 ubiquitin-protein transferase RBX1,Protein ZYP,RING finger protein 75,RING-box protein 1,Rbx1,Regulator of cullins 1,ROC1 |
| 4 | D (S) | S-phase kinase-associated protein 1 | polymer | 163 | 18680.0 | 1 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
| 5 | E, F, G (R) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
C: 1 - 1698 (UniProt: Q14999)
F: 1 - 598 (UniProt: Q8N3Y1)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Arg 813 | Gln 813 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 290163.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 290359.4 |
