7Z2M
Crystal Structure of the 11.003 Fab in complex with human IL-17A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, L (A, C, E, L) | 11.003 Fab light-chain | polymer | 214 | 23640.3 | 4 | Homo sapiens (human) | ||
| 2 | B, D, F, H (B, D, F, H) | 11.003 Fab heavy-chain | polymer | 225 | 24115.1 | 4 | Homo sapiens (human) | ||
| 3 | G, I, J, K (G, I, J, K) | Interleukin-17A | polymer | 122 | 14119.9 | 4 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 4 | M, N, O (B, C, F) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | AA, P, Q, R, S... (L, A, B, C, D...) | water | water | 18.0 | 1507 | Chemie (HOH) |
Sequence modifications
G, I, J, K: 11 - 132 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Ser 106 | Cys 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 247500.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 276.3 | |
| All* | Total formula weight | 247777.1 |
