7Z2M

Crystal Structure of the 11.003 Fab in complex with human IL-17A

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0002225	biological_process	positive regulation of antimicrobial peptide production
G	0002250	biological_process	adaptive immune response
G	0002376	biological_process	immune system process
G	0005125	molecular_function	cytokine activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005886	cellular_component	plasma membrane
G	0006915	biological_process	apoptotic process
G	0006954	biological_process	inflammatory response
G	0006955	biological_process	immune response
G	0007219	biological_process	Notch signaling pathway
G	0007267	biological_process	cell-cell signaling
G	0008219	biological_process	cell death
G	0009611	biological_process	response to wounding
G	0009897	cellular_component	external side of plasma membrane
G	0010467	biological_process	gene expression
G	0030216	biological_process	keratinocyte differentiation
G	0032731	biological_process	positive regulation of interleukin-1 beta production
G	0032735	biological_process	positive regulation of interleukin-12 production
G	0032739	biological_process	positive regulation of interleukin-16 production
G	0032747	biological_process	positive regulation of interleukin-23 production
G	0032755	biological_process	positive regulation of interleukin-6 production
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0038173	biological_process	interleukin-17A-mediated signaling pathway
G	0042803	molecular_function	protein homodimerization activity
G	0043616	biological_process	keratinocyte proliferation
G	0045087	biological_process	innate immune response
G	0045672	biological_process	positive regulation of osteoclast differentiation
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046982	molecular_function	protein heterodimerization activity
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0050830	biological_process	defense response to Gram-positive bacterium
G	0050832	biological_process	defense response to fungus
G	0060729	biological_process	intestinal epithelial structure maintenance
G	0070534	biological_process	protein K63-linked ubiquitination
G	0072537	biological_process	fibroblast activation
G	0072538	biological_process	T-helper 17 type immune response
G	0080090	biological_process	regulation of primary metabolic process
G	0097400	biological_process	interleukin-17-mediated signaling pathway
G	0097530	biological_process	granulocyte migration
G	0106015	biological_process	negative regulation of inflammatory response to wounding
G	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
G	1903348	biological_process	positive regulation of bicellular tight junction assembly
G	1903557	biological_process	positive regulation of tumor necrosis factor superfamily cytokine production
G	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
I	0002225	biological_process	positive regulation of antimicrobial peptide production
I	0002250	biological_process	adaptive immune response
I	0002376	biological_process	immune system process
I	0005125	molecular_function	cytokine activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005886	cellular_component	plasma membrane
I	0006915	biological_process	apoptotic process
I	0006954	biological_process	inflammatory response
I	0006955	biological_process	immune response
I	0007219	biological_process	Notch signaling pathway
I	0007267	biological_process	cell-cell signaling
I	0008219	biological_process	cell death
I	0009611	biological_process	response to wounding
I	0009897	cellular_component	external side of plasma membrane
I	0010467	biological_process	gene expression
I	0030216	biological_process	keratinocyte differentiation
I	0032731	biological_process	positive regulation of interleukin-1 beta production
I	0032735	biological_process	positive regulation of interleukin-12 production
I	0032739	biological_process	positive regulation of interleukin-16 production
I	0032747	biological_process	positive regulation of interleukin-23 production
I	0032755	biological_process	positive regulation of interleukin-6 production
I	0032760	biological_process	positive regulation of tumor necrosis factor production
I	0038173	biological_process	interleukin-17A-mediated signaling pathway
I	0042803	molecular_function	protein homodimerization activity
I	0043616	biological_process	keratinocyte proliferation
I	0045087	biological_process	innate immune response
I	0045672	biological_process	positive regulation of osteoclast differentiation
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046982	molecular_function	protein heterodimerization activity
I	0050829	biological_process	defense response to Gram-negative bacterium
I	0050830	biological_process	defense response to Gram-positive bacterium
I	0050832	biological_process	defense response to fungus
I	0060729	biological_process	intestinal epithelial structure maintenance
I	0070534	biological_process	protein K63-linked ubiquitination
I	0072537	biological_process	fibroblast activation
I	0072538	biological_process	T-helper 17 type immune response
I	0080090	biological_process	regulation of primary metabolic process
I	0097400	biological_process	interleukin-17-mediated signaling pathway
I	0097530	biological_process	granulocyte migration
I	0106015	biological_process	negative regulation of inflammatory response to wounding
I	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
I	1903348	biological_process	positive regulation of bicellular tight junction assembly
I	1903557	biological_process	positive regulation of tumor necrosis factor superfamily cytokine production
I	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
J	0002225	biological_process	positive regulation of antimicrobial peptide production
J	0002250	biological_process	adaptive immune response
J	0002376	biological_process	immune system process
J	0005125	molecular_function	cytokine activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005886	cellular_component	plasma membrane
J	0006915	biological_process	apoptotic process
J	0006954	biological_process	inflammatory response
J	0006955	biological_process	immune response
J	0007219	biological_process	Notch signaling pathway
J	0007267	biological_process	cell-cell signaling
J	0008219	biological_process	cell death
J	0009611	biological_process	response to wounding
J	0009897	cellular_component	external side of plasma membrane
J	0010467	biological_process	gene expression
J	0030216	biological_process	keratinocyte differentiation
J	0032731	biological_process	positive regulation of interleukin-1 beta production
J	0032735	biological_process	positive regulation of interleukin-12 production
J	0032739	biological_process	positive regulation of interleukin-16 production
J	0032747	biological_process	positive regulation of interleukin-23 production
J	0032755	biological_process	positive regulation of interleukin-6 production
J	0032760	biological_process	positive regulation of tumor necrosis factor production
J	0038173	biological_process	interleukin-17A-mediated signaling pathway
J	0042803	molecular_function	protein homodimerization activity
J	0043616	biological_process	keratinocyte proliferation
J	0045087	biological_process	innate immune response
J	0045672	biological_process	positive regulation of osteoclast differentiation
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0046982	molecular_function	protein heterodimerization activity
J	0050829	biological_process	defense response to Gram-negative bacterium
J	0050830	biological_process	defense response to Gram-positive bacterium
J	0050832	biological_process	defense response to fungus
J	0060729	biological_process	intestinal epithelial structure maintenance
J	0070534	biological_process	protein K63-linked ubiquitination
J	0072537	biological_process	fibroblast activation
J	0072538	biological_process	T-helper 17 type immune response
J	0080090	biological_process	regulation of primary metabolic process
J	0097400	biological_process	interleukin-17-mediated signaling pathway
J	0097530	biological_process	granulocyte migration
J	0106015	biological_process	negative regulation of inflammatory response to wounding
J	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
J	1903348	biological_process	positive regulation of bicellular tight junction assembly
J	1903557	biological_process	positive regulation of tumor necrosis factor superfamily cytokine production
J	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
K	0002225	biological_process	positive regulation of antimicrobial peptide production
K	0002250	biological_process	adaptive immune response
K	0002376	biological_process	immune system process
K	0005125	molecular_function	cytokine activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005886	cellular_component	plasma membrane
K	0006915	biological_process	apoptotic process
K	0006954	biological_process	inflammatory response
K	0006955	biological_process	immune response
K	0007219	biological_process	Notch signaling pathway
K	0007267	biological_process	cell-cell signaling
K	0008219	biological_process	cell death
K	0009611	biological_process	response to wounding
K	0009897	cellular_component	external side of plasma membrane
K	0010467	biological_process	gene expression
K	0030216	biological_process	keratinocyte differentiation
K	0032731	biological_process	positive regulation of interleukin-1 beta production
K	0032735	biological_process	positive regulation of interleukin-12 production
K	0032739	biological_process	positive regulation of interleukin-16 production
K	0032747	biological_process	positive regulation of interleukin-23 production
K	0032755	biological_process	positive regulation of interleukin-6 production
K	0032760	biological_process	positive regulation of tumor necrosis factor production
K	0038173	biological_process	interleukin-17A-mediated signaling pathway
K	0042803	molecular_function	protein homodimerization activity
K	0043616	biological_process	keratinocyte proliferation
K	0045087	biological_process	innate immune response
K	0045672	biological_process	positive regulation of osteoclast differentiation
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0046982	molecular_function	protein heterodimerization activity
K	0050829	biological_process	defense response to Gram-negative bacterium
K	0050830	biological_process	defense response to Gram-positive bacterium
K	0050832	biological_process	defense response to fungus
K	0060729	biological_process	intestinal epithelial structure maintenance
K	0070534	biological_process	protein K63-linked ubiquitination
K	0072537	biological_process	fibroblast activation
K	0072538	biological_process	T-helper 17 type immune response
K	0080090	biological_process	regulation of primary metabolic process
K	0097400	biological_process	interleukin-17-mediated signaling pathway
K	0097530	biological_process	granulocyte migration
K	0106015	biological_process	negative regulation of inflammatory response to wounding
K	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
K	1903348	biological_process	positive regulation of bicellular tight junction assembly
K	1903557	biological_process	positive regulation of tumor necrosis factor superfamily cytokine production
K	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR199-HIS205
A	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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