7YYN
Mammalian Dicer in the dicing state with pre-miR-15a substrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | 59-nt precursor of miR-15a | polymer | 59 | 19017.3 | 1 | GenBank (66773608) | Mus musculus | |
| 2 | A | Isoform 2 of Endoribonuclease Dicer | polymer | 1765 | 200040.9 | 1 | UniProt (Q8R418) Pfam (PF20930) Pfam (PF00271) Pfam (PF03368) Pfam (PF20931) Pfam (PF02170) Pfam (PF00636) Pfam (PF20932) In PDB | Mus musculus (house mouse) | Double-strand-specific ribonuclease mDCR-1 |
Sequence modifications
A: 2 - 1678 (UniProt: Q8R418)
| PDB | External Database | Details |
|---|---|---|
| Met -51 | - | initiating methionine |
| Val -50 | - | expression tag |
| Trp -49 | - | expression tag |
| Ser -48 | - | expression tag |
| His -47 | - | expression tag |
| Pro -46 | - | expression tag |
| Gln -45 | - | expression tag |
| Phe -44 | - | expression tag |
| Glu -43 | - | expression tag |
| Lys -42 | - | expression tag |
| Gly -41 | - | expression tag |
| Gly -40 | - | expression tag |
| Gly -39 | - | expression tag |
| Ser -38 | - | expression tag |
| Gly -37 | - | expression tag |
| Gly -36 | - | expression tag |
| Gly -35 | - | expression tag |
| Ser -34 | - | expression tag |
| Gly -33 | - | expression tag |
| Gly -32 | - | expression tag |
| Ser -31 | - | expression tag |
| Ala -30 | - | expression tag |
| Trp -29 | - | expression tag |
| Ser -28 | - | expression tag |
| His -27 | - | expression tag |
| Pro -26 | - | expression tag |
| Gln -25 | - | expression tag |
| Phe -24 | - | expression tag |
| Glu -23 | - | expression tag |
| Lys -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Asp -20 | - | expression tag |
| Tyr -19 | - | expression tag |
| Pro -18 | - | expression tag |
| Tyr -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Val -15 | - | expression tag |
| Pro -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Tyr -12 | - | expression tag |
| Ala -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Thr -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Val 0 | - | expression tag |
| Asp 1 | - | expression tag |
| Ser 872 | Thr 872 | conflict |
| Ala 1322 | Glu 1322 | engineered mutation |
| Ser 1381 | Ala 1381 | conflict |
| Ala 1569 | Glu 1569 | engineered mutation |
| Gly 1679 | - | expression tag |
| Arg 1680 | - | expression tag |
| Gly 1681 | - | expression tag |
| Glu 1682 | - | expression tag |
| Asn 1683 | - | expression tag |
| Leu 1684 | - | expression tag |
| Tyr 1685 | - | expression tag |
| Phe 1686 | - | expression tag |
| Gln 1687 | - | expression tag |
| Gly 1688 | - | expression tag |
| Ala 1689 | - | expression tag |
| Ser 1690 | - | expression tag |
| Asp 1691 | - | expression tag |
| Tyr 1692 | - | expression tag |
| Lys 1693 | - | expression tag |
| Asp 1694 | - | expression tag |
| His 1695 | - | expression tag |
| Asp 1696 | - | expression tag |
| Gly 1697 | - | expression tag |
| Asp 1698 | - | expression tag |
| Tyr 1699 | - | expression tag |
| Lys 1700 | - | expression tag |
| Asp 1701 | - | expression tag |
| His 1702 | - | expression tag |
| Asp 1703 | - | expression tag |
| Gly 1704 | - | expression tag |
| Ser 1705 | - | expression tag |
| His 1706 | - | expression tag |
| His 1707 | - | expression tag |
| His 1708 | - | expression tag |
| His 1709 | - | expression tag |
| His 1710 | - | expression tag |
| His 1711 | - | expression tag |
| His 1712 | - | expression tag |
| His 1713 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 219058.2 | |
| All* | Total formula weight | 219058.2 |
