7YYN

Mammalian Dicer in the dicing state with pre-miR-15a substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004525	molecular_function	ribonuclease III activity
A	0006396	biological_process	RNA processing
A	0016891	molecular_function	RNA endonuclease activity, producing 5'-phosphomonoesters
A	0030422	biological_process	siRNA processing
A	0031054	biological_process	pre-miRNA processing

Functional Information from PROSITE/UniProt

site_id	PS00517
Number of Residues	9
Details	RNASE_3_1 Ribonuclease III family signature. QRLEFLGDA

Chain	Residue	Details
A	GLN1458-ALA1466

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ILE64
A	GLU1078
A	GLU1157
A	GLU1160

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9UPY3

Chain	Residue	Details
A	GLU1461
A	ASP1566
A	ALA1569

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Important for activity => ECO:0000269|PubMed:18268334

Chain	Residue	Details
A	LYS1562

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site_id	SWS_FT_FI4
Number of Residues	7
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9UPY3

Chain	Residue	Details
A	SER175
A	SER177
A	SER778
A	SER922
A	SER1218
A	SER1228
A	SER1624

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER1226

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