7YX9

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	HLA class II histocompatibility antigen, DR alpha chain	polymer	192	22207.1	2	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	MHC class II antigen DRA
2	B, D (B, D)	MHC class II antigen	polymer	217	24512.2	2	UniProt (A0A4E9DJJ3) Pfam (PF00969) Pfam (PF07654)	Homo sapiens (human)
3	E, F (E, G)	CLIP 103-107	polymer	15	1676.1	2	UniProt (by SIFTS) (P04233)	Homo sapiens (human)
4	G, H, I, J, K... (A, B, C, D)	1,2-ETHANEDIOL	non-polymer		62.1	11	Chemie (EDO)
5	R, S, T, U, V... (A, B, C, D, E...)	water	water		18.0	907	Chemie (HOH)

Sequence modifications

A, C: 1 - 191 (UniProt: P01903)

PDB	External Database	Details
Val 192	-	expression tag

B, D: 34 - 231 (UniProt: A0A4E9DJJ3)

PDB	External Database	Details
Gly 16	-	expression tag
Asn 17	-	expression tag
Ser 18	-	expression tag
Gly 19	-	expression tag
Gly 20	-	expression tag
Gly 21	-	expression tag
Ser 22	-	expression tag
Leu 23	-	expression tag
Val 24	-	expression tag
Pro 25	-	expression tag
Arg 26	-	expression tag
Gly 27	-	expression tag
Ser 28	-	expression tag
Gly 29	-	expression tag
Gly 30	-	expression tag
Gly 31	-	expression tag
Gly 32	-	expression tag
Ser 33	-	expression tag
Val 232	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	96790.8
Non-Polymers*	Number of molecules	11
	Total formula weight	682.7
All*	Total formula weight	97473.6

*Water molecules are not included.