7YEH
Cryo-EM structure of human OGT-OGA complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | polymer | 1052 | 117953.4 | 2 | UniProt (O15294) Pfam (PF13414) Pfam (PF13844) Pfam (PF13181) Pfam (PF00515) Pfam (PF13424) | Homo sapiens (human) | O-GlcNAc transferase subunit p110,O-linked N-acetylglucosamine transferase 110 kDa subunit,OGT |
| 2 | C, D (C, D) | Protein O-GlcNAcase | polymer | 916 | 103020.9 | 2 | UniProt (O60502) Pfam (PF07555) | Homo sapiens (human) | OGA,Beta-N-acetylglucosaminidase,Beta-N-acetylhexosaminidase,Beta-hexosaminidase,Meningioma-expressed antigen 5,N-acetyl-beta-D-glucosaminidase,N-acetyl-beta-glucosaminidase,Nuclear cytoplasmic O-GlcNAcase and acetyltransferase,NCOAT |
| 3 | E (A) | URIDINE-5'-DIPHOSPHATE | non-polymer | 404.2 | 1 | Chemie (UDP) | |||
| 4 | F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
B, A: 1 - 1046 (UniProt: O15294)
| PDB | External Database | Details |
|---|---|---|
| Met 25 | Ala 25 | conflict |
| Glu 67 | Gln 67 | conflict |
| His 1047 | - | expression tag |
| His 1048 | - | expression tag |
| His 1049 | - | expression tag |
| His 1050 | - | expression tag |
| His 1051 | - | expression tag |
| His 1052 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 441948.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 625.4 | |
| All* | Total formula weight | 442574.0 |
