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7YEH

Cryo-EM structure of human OGT-OGA complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000123cellular_componenthistone acetyltransferase complex
A0000423biological_processmitophagy
A0000432biological_processpositive regulation of transcription from RNA polymerase II promoter by glucose
A0005515molecular_functionprotein binding
A0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006110biological_processregulation of glycolytic process
A0006111biological_processregulation of gluconeogenesis
A0006325biological_processchromatin organization
A0006357biological_processregulation of transcription by RNA polymerase II
A0006486biological_processprotein glycosylation
A0006493biological_processprotein O-linked glycosylation
A0006915biological_processapoptotic process
A0007165biological_processsignal transduction
A0007584biological_processresponse to nutrient
A0008289molecular_functionlipid binding
A0008375molecular_functionacetylglucosaminyltransferase activity
A0016485biological_processprotein processing
A0016757molecular_functionglycosyltransferase activity
A0017122cellular_componentprotein N-acetylglucosaminyltransferase complex
A0030097biological_processhemopoiesis
A0030336biological_processnegative regulation of cell migration
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0031397biological_processnegative regulation of protein ubiquitination
A0031490molecular_functionchromatin DNA binding
A0031966cellular_componentmitochondrial membrane
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032868biological_processresponse to insulin
A0032922biological_processcircadian regulation of gene expression
A0032991cellular_componentprotein-containing complex
A0035020biological_processregulation of Rac protein signal transduction
A0042995cellular_componentcell projection
A0044545cellular_componentNSL complex
A0045202cellular_componentsynapse
A0045727biological_processpositive regulation of translation
A0045862biological_processpositive regulation of proteolysis
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046626biological_processregulation of insulin receptor signaling pathway
A0046889biological_processpositive regulation of lipid biosynthetic process
A0048511biological_processrhythmic process
A0051963biological_processregulation of synapse assembly
A0060544biological_processregulation of necroptotic process
A0070822cellular_componentSin3-type complex
A0071333biological_processcellular response to glucose stimulus
A0097363molecular_functionprotein O-acetylglucosaminyltransferase activity
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098978cellular_componentglutamatergic synapse
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0160076biological_processnegative regulation of non-canonical inflammasome complex assembly
A1902455biological_processnegative regulation of stem cell population maintenance
A1902459biological_processpositive regulation of stem cell population maintenance
A1904263biological_processpositive regulation of TORC1 signaling
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000123cellular_componenthistone acetyltransferase complex
B0000423biological_processmitophagy
B0000432biological_processpositive regulation of transcription from RNA polymerase II promoter by glucose
B0005515molecular_functionprotein binding
B0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006110biological_processregulation of glycolytic process
B0006111biological_processregulation of gluconeogenesis
B0006325biological_processchromatin organization
B0006357biological_processregulation of transcription by RNA polymerase II
B0006486biological_processprotein glycosylation
B0006493biological_processprotein O-linked glycosylation
B0006915biological_processapoptotic process
B0007165biological_processsignal transduction
B0007584biological_processresponse to nutrient
B0008289molecular_functionlipid binding
B0008375molecular_functionacetylglucosaminyltransferase activity
B0016485biological_processprotein processing
B0016757molecular_functionglycosyltransferase activity
B0017122cellular_componentprotein N-acetylglucosaminyltransferase complex
B0030097biological_processhemopoiesis
B0030336biological_processnegative regulation of cell migration
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0031397biological_processnegative regulation of protein ubiquitination
B0031490molecular_functionchromatin DNA binding
B0031966cellular_componentmitochondrial membrane
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032868biological_processresponse to insulin
B0032922biological_processcircadian regulation of gene expression
B0032991cellular_componentprotein-containing complex
B0035020biological_processregulation of Rac protein signal transduction
B0042995cellular_componentcell projection
B0044545cellular_componentNSL complex
B0045202cellular_componentsynapse
B0045727biological_processpositive regulation of translation
B0045862biological_processpositive regulation of proteolysis
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046626biological_processregulation of insulin receptor signaling pathway
B0046889biological_processpositive regulation of lipid biosynthetic process
B0048511biological_processrhythmic process
B0051963biological_processregulation of synapse assembly
B0060544biological_processregulation of necroptotic process
B0070822cellular_componentSin3-type complex
B0071333biological_processcellular response to glucose stimulus
B0097363molecular_functionprotein O-acetylglucosaminyltransferase activity
B0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B0098978cellular_componentglutamatergic synapse
B0120162biological_processpositive regulation of cold-induced thermogenesis
B0160076biological_processnegative regulation of non-canonical inflammasome complex assembly
B1902455biological_processnegative regulation of stem cell population maintenance
B1902459biological_processpositive regulation of stem cell population maintenance
B1904263biological_processpositive regulation of TORC1 signaling
C0004415molecular_functionhyalurononglucosaminidase activity
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006044biological_processN-acetylglucosamine metabolic process
C0006493biological_processprotein O-linked glycosylation
C0006516biological_processglycoprotein catabolic process
C0006517biological_processprotein deglycosylation
C0009100biological_processglycoprotein metabolic process
C0016020cellular_componentmembrane
C0016231molecular_functionbeta-N-acetylglucosaminidase activity
C0016798molecular_functionhydrolase activity, acting on glycosyl bonds
C0042802molecular_functionidentical protein binding
C0102571molecular_function[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
C1901135biological_processcarbohydrate derivative metabolic process
D0004415molecular_functionhyalurononglucosaminidase activity
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006044biological_processN-acetylglucosamine metabolic process
D0006493biological_processprotein O-linked glycosylation
D0006516biological_processglycoprotein catabolic process
D0006517biological_processprotein deglycosylation
D0009100biological_processglycoprotein metabolic process
D0016020cellular_componentmembrane
D0016231molecular_functionbeta-N-acetylglucosaminidase activity
D0016798molecular_functionhydrolase activity, acting on glycosyl bonds
D0042802molecular_functionidentical protein binding
D0102571molecular_function[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
D1901135biological_processcarbohydrate derivative metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01353, ECO:0000305|PubMed:16533067
ChainResidueDetails
CASP175
DASP175

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:28939839, ECO:0007744|PDB:5VVT
ChainResidueDetails
CGLY67
DASP174
DASP175
DTYR219
DASP285
DASN313
CLYS98
CASP174
CASP175
CTYR219
CASP285
CASN313
DGLY67
DLYS98

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by caspase-3 => ECO:0000269|PubMed:18586680
ChainResidueDetails
CASP413
DASP413

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER364
DSER364
ASER3
ASER4

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER20
ASER20

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260
ChainResidueDetails
BTHR454
ATHR454

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P56558
ChainResidueDetails
BTYR989
ATYR989

site_idSWS_FT_FI8
Number of Residues4
DetailsCARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000250|UniProtKB:Q8CGY8
ChainResidueDetails
BSER3
BSER4
ASER3
ASER4

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473
ChainResidueDetails
BSER399
ASER399

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PDB entries from 2024-07-17

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