7Y38

Molecular architecture of the chikungunya virus replication complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	mRNA-capping enzyme nsP1,affinity-tag (strepII-3XFLAG)	polymer	573	64328.9	12	UniProt (Q8JUX6) Pfam (PF01660)	Chikungunya virus strain S27-African prototype	Non-structural protein 1
2	M (X)	RNA-directed RNA polymerase nsP4	polymer	611	68373.3	1	UniProt (by SIFTS) (O90368)	Onyong-nyong virus
3	N (Y)	Protease nsP2	polymer	798	89599.8	1	UniProt (Q8JUX6) Pfam (PF20896) Pfam (PF01443) Pfam (PF01707)	Chikungunya virus strain S27-African prototype	Non-structural protein 2,nsP2
4	O (Z)	RNA (5'-R(PCPCP*A)-3')	polymer	3	894.6	1		in vitro transcription vector pT7-TP(deltai)
5	BA, EA, HA, KA, NA... (E, F, G, H, I...)	ZINC ION	non-polymer		65.4	12	Chemie (ZN)
6	AA, DA, GA, IA, LA... (D, E, F, G, H...)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	12	Chemie (ATP)
7	CA, FA, JA, MA, PA... (E, F, G, H, I...)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	12	Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 1 - 516 (UniProt: Q8JUX6)

PDB	External Database	Details
Ala 37	His 37	engineered mutation

A, B, C, D, E, F, G, H, I, J, K, L: 517 - 552 (PDB: 7Y38)
A, B, C, D, E, F, G, H, I, J, K, L: 553 - 570 (UniProt: Q8JUX6)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.