7XY8

Crystal structure of antibody Fab fragment in complex with CD147(EMMPIRIN)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isoform 2 of Basigin	polymer	205	22503.9	2	UniProt (P35613) Pfam (PF13927)	Homo sapiens (human)	5F7,Collagenase stimulatory factor,Extracellular matrix metalloproteinase inducer,EMMPRIN,Hepatoma-associated antigen,HAb18G,Leukocyte activation antigen M6,OK blood group antigen,Tumor cell-derived collagenase stimulatory factor,TCSF
2	C, D (H, I)	heavy chain	polymer	236	25277.3	2		synthetic construct
3	E, F (L, M)	light chain	polymer	214	23432.9	2		synthetic construct
4	G, H, I, J, K... (A, B, H, I, L...)	water	water		18.0	187	Chemie (HOH)

Sequence modifications

A, B: 22 - 205 (UniProt: P35613)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 2	-	expression tag
Ser 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Ser 11	-	expression tag
Ser 12	-	expression tag
Gly 13	-	expression tag
Glu 14	-	expression tag
Asn 15	-	expression tag
Leu 16	-	expression tag
Tyr 17	-	expression tag
Phe 18	-	expression tag
Gln 19	-	expression tag
Gly 20	-	expression tag
Ser 21	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	142428.3
All*	Total formula weight	142428.3

*Water molecules are not included.