7XQ8

Structure of human B-cell antigen receptor of the IgM isotype

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, v	Chimera of Heavy chain of VRC01 antibody Fab and Isoform 2 of Immunoglobulin heavy constant mu	polymer	614	67895.6	2	UniProt (P01871-2) Pfam (PF07654) UniProt (by SIFTS) (P01871) In PDB	Homo sapiens (human)	Ig mu chain C region,Ig mu chain C region BOT,Ig mu chain C region GAL,Ig mu chain C region OU
2	L, R	Light chain of Fab fragments of the VRC01 antibody,Immunoglobulin kappa constant	polymer	250	27350.2	2	UniProt (P01834) Pfam (PF07654) In PDB	Homo sapiens (human)
3	A	B-cell antigen receptor complex-associated protein alpha chain	polymer	257	28144.6	1	UniProt (P11912) Pfam (PF13927) Pfam (PF02189) In PDB	Homo sapiens (human)	Ig-alpha,MB-1 membrane glycoprotein,Membrane-bound immunoglobulin-associated protein,Surface IgM-associated protein
4	B	B-cell antigen receptor complex-associated protein beta chain	polymer	260	29163.1	1	UniProt (P40259) Pfam (PF07686) In PDB	Homo sapiens (human)	B-cell-specific glycoprotein B29,Ig-beta,Immunoglobulin-associated B29 protein
5	C, v, A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	14	Chemie (NAG)

Sequence modifications

C, v: -8 - 123 (PDB: 7XQ8)
C, v: 124 - 597 (UniProt: P01871-2)
L, R: -39 - 109 (PDB: 7XQ8)
L, R: 110 - 216 (UniProt: P01834)
A: 1 - 226 (UniProt: P11912)

PDB	External Database	Details
Ala 227	-	expression tag
Ala 228	-	expression tag
Ala 229	-	expression tag
Trp 230	-	expression tag
Ser 231	-	expression tag
His 232	-	expression tag
Pro 233	-	expression tag
Gln 234	-	expression tag
Phe 235	-	expression tag
Glu 236	-	expression tag
Lys 237	-	expression tag
Gly 238	-	expression tag
Gly 239	-	expression tag
Gly 240	-	expression tag
Ser 241	-	expression tag
Gly 242	-	expression tag
Gly 243	-	expression tag
Gly 244	-	expression tag
Ser 245	-	expression tag
Gly 246	-	expression tag
Gly 247	-	expression tag
Ser 248	-	expression tag
Ala 249	-	expression tag
Trp 250	-	expression tag
Ser 251	-	expression tag
His 252	-	expression tag
Pro 253	-	expression tag
Gln 254	-	expression tag
Phe 255	-	expression tag
Glu 256	-	expression tag
Lys 257	-	expression tag

B: 1 - 229 (UniProt: P40259)

PDB	External Database	Details
Ala 230	-	expression tag
Ala 231	-	expression tag
Ala 232	-	expression tag
Trp 233	-	expression tag
Ser 234	-	expression tag
His 235	-	expression tag
Pro 236	-	expression tag
Gln 237	-	expression tag
Phe 238	-	expression tag
Glu 239	-	expression tag
Lys 240	-	expression tag
Gly 241	-	expression tag
Gly 242	-	expression tag
Gly 243	-	expression tag
Ser 244	-	expression tag
Gly 245	-	expression tag
Gly 246	-	expression tag
Gly 247	-	expression tag
Ser 248	-	expression tag
Gly 249	-	expression tag
Gly 250	-	expression tag
Ser 251	-	expression tag
Ala 252	-	expression tag
Trp 253	-	expression tag
Ser 254	-	expression tag
His 255	-	expression tag
Pro 256	-	expression tag
Gln 257	-	expression tag
Phe 258	-	expression tag
Glu 259	-	expression tag
Lys 260	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	247799.4
Non-Polymers*	Number of molecules	14
	Total formula weight	3096.9
All*	Total formula weight	250896.3

*Water molecules are not included.