Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7XQ8

Structure of human B-cell antigen receptor of the IgM isotype

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0007166	biological_process	cell surface receptor signaling pathway
A	0016020	cellular_component	membrane
A	0019815	cellular_component	B cell receptor complex
A	0050853	biological_process	B cell receptor signaling pathway
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0007166	biological_process	cell surface receptor signaling pathway
B	0016020	cellular_component	membrane
B	0019815	cellular_component	B cell receptor complex
B	0050853	biological_process	B cell receptor signaling pathway
C	0002250	biological_process	adaptive immune response
C	0003697	molecular_function	single-stranded DNA binding
C	0003823	molecular_function	antigen binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006958	biological_process	complement activation, classical pathway
C	0009986	cellular_component	cell surface
C	0019731	biological_process	antibacterial humoral response
C	0019814	cellular_component	immunoglobulin complex
C	0031210	molecular_function	phosphatidylcholine binding
C	0034987	molecular_function	immunoglobulin receptor binding
C	0042571	cellular_component	immunoglobulin complex, circulating
C	0042834	molecular_function	peptidoglycan binding
C	0045087	biological_process	innate immune response
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0050853	biological_process	B cell receptor signaling pathway
C	0070062	cellular_component	extracellular exosome
C	0071753	cellular_component	IgM immunoglobulin complex
C	0071756	cellular_component	pentameric IgM immunoglobulin complex
C	0071757	cellular_component	hexameric IgM immunoglobulin complex
C	0072562	cellular_component	blood microparticle
L	0002250	biological_process	adaptive immune response
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0071738	cellular_component	IgD immunoglobulin complex
L	0071742	cellular_component	IgE immunoglobulin complex
L	0071745	cellular_component	IgA immunoglobulin complex
L	0071753	cellular_component	IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle
R	0002250	biological_process	adaptive immune response
R	0003823	molecular_function	antigen binding
R	0005576	cellular_component	extracellular region
R	0005615	cellular_component	extracellular space
R	0005886	cellular_component	plasma membrane
R	0006955	biological_process	immune response
R	0016064	biological_process	immunoglobulin mediated immune response
R	0019814	cellular_component	immunoglobulin complex
R	0050853	biological_process	B cell receptor signaling pathway
R	0070062	cellular_component	extracellular exosome
R	0071735	cellular_component	IgG immunoglobulin complex
R	0071738	cellular_component	IgD immunoglobulin complex
R	0071742	cellular_component	IgE immunoglobulin complex
R	0071745	cellular_component	IgA immunoglobulin complex
R	0071753	cellular_component	IgM immunoglobulin complex
R	0072562	cellular_component	blood microparticle
v	0002250	biological_process	adaptive immune response
v	0003697	molecular_function	single-stranded DNA binding
v	0003823	molecular_function	antigen binding
v	0005576	cellular_component	extracellular region
v	0005615	cellular_component	extracellular space
v	0005886	cellular_component	plasma membrane
v	0006958	biological_process	complement activation, classical pathway
v	0009986	cellular_component	cell surface
v	0019731	biological_process	antibacterial humoral response
v	0019814	cellular_component	immunoglobulin complex
v	0031210	molecular_function	phosphatidylcholine binding
v	0034987	molecular_function	immunoglobulin receptor binding
v	0042571	cellular_component	immunoglobulin complex, circulating
v	0042834	molecular_function	peptidoglycan binding
v	0045087	biological_process	innate immune response
v	0050829	biological_process	defense response to Gram-negative bacterium
v	0050853	biological_process	B cell receptor signaling pathway
v	0070062	cellular_component	extracellular exosome
v	0071753	cellular_component	IgM immunoglobulin complex
v	0071756	cellular_component	pentameric IgM immunoglobulin complex
v	0071757	cellular_component	hexameric IgM immunoglobulin complex
v	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FTCRVDH

Chain	Residue	Details
C	PHE318-HIS324
C	PHE424-HIS430
C	TYR534-HIS540
L	TYR194-HIS200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	898
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
C	GLY124-THR573
v	GLY124-THR573

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	ALA574-PHE594
v	ALA574-PHE594

site_id	SWS_FT_FI3
Number of Residues	4
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
C	LYS595-LYS597
v	LYS595-LYS597

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:14760718, ECO:0000269\|PubMed:16422668, ECO:0000269\|PubMed:19139490, ECO:0000269\|PubMed:19159218, ECO:0007744\|PDB:2AGJ

Chain	Residue	Details
C	ASN169
v	ASN169

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:19139490, ECO:0000269\|PubMed:35981043, ECO:0007744\|PDB:7XQ8

Chain	Residue	Details
C	ASN332
v	ASN332

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:35981043, ECO:0000269\|PubMed:4742735, ECO:0007744\|PDB:7XQ8

Chain	Residue	Details
C	ASN395
v	ASN395

site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:35981043, ECO:0000269\|PubMed:4742735, ECO:0007744\|PDB:7XQ8

Chain	Residue	Details
C	ASN402
v	ASN402

site_id	SWS_FT_FI8
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269\|PubMed:35981043, ECO:0007744\|PDB:7XQ8

Chain	Residue	Details
A	ASN57
A	ASN63
A	ASN73
A	ASN88
A	ASN97
A	ASN112

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)