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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7XQ8

Structure of human B-cell antigen receptor of the IgM isotype

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0007166biological_processcell surface receptor signaling pathway
A0016020cellular_componentmembrane
B0004888molecular_functiontransmembrane signaling receptor activity
B0007166biological_processcell surface receptor signaling pathway
B0016020cellular_componentmembrane
C0002250biological_processadaptive immune response
C0003697molecular_functionsingle-stranded DNA binding
C0003823molecular_functionantigen binding
C0005576cellular_componentextracellular region
C0005886cellular_componentplasma membrane
C0006952biological_processdefense response
C0006955biological_processimmune response
C0009986cellular_componentcell surface
C0019731biological_processantibacterial humoral response
C0019814cellular_componentimmunoglobulin complex
C0031210molecular_functionphosphatidylcholine binding
C0034987molecular_functionimmunoglobulin receptor binding
C0042834molecular_functionpeptidoglycan binding
C0045087biological_processinnate immune response
C0050829biological_processdefense response to Gram-negative bacterium
C0050853biological_processB cell receptor signaling pathway
C0070062cellular_componentextracellular exosome
C0071753cellular_componentIgM immunoglobulin complex
C0071756cellular_componentpentameric IgM immunoglobulin complex
C0071757cellular_componenthexameric IgM immunoglobulin complex
C0072562cellular_componentblood microparticle
L0002250biological_processadaptive immune response
L0003823molecular_functionantigen binding
L0005576cellular_componentextracellular region
L0005886cellular_componentplasma membrane
L0006955biological_processimmune response
L0016064biological_processimmunoglobulin mediated immune response
L0050853biological_processB cell receptor signaling pathway
L0070062cellular_componentextracellular exosome
L0071735cellular_componentIgG immunoglobulin complex
L0071738cellular_componentIgD immunoglobulin complex
L0071742cellular_componentIgE immunoglobulin complex
L0071745cellular_componentIgA immunoglobulin complex
L0071753cellular_componentIgM immunoglobulin complex
L0072562cellular_componentblood microparticle
R0002250biological_processadaptive immune response
R0003823molecular_functionantigen binding
R0005576cellular_componentextracellular region
R0005886cellular_componentplasma membrane
R0006955biological_processimmune response
R0016064biological_processimmunoglobulin mediated immune response
R0050853biological_processB cell receptor signaling pathway
R0070062cellular_componentextracellular exosome
R0071735cellular_componentIgG immunoglobulin complex
R0071738cellular_componentIgD immunoglobulin complex
R0071742cellular_componentIgE immunoglobulin complex
R0071745cellular_componentIgA immunoglobulin complex
R0071753cellular_componentIgM immunoglobulin complex
R0072562cellular_componentblood microparticle
v0002250biological_processadaptive immune response
v0003697molecular_functionsingle-stranded DNA binding
v0003823molecular_functionantigen binding
v0005576cellular_componentextracellular region
v0005886cellular_componentplasma membrane
v0006952biological_processdefense response
v0006955biological_processimmune response
v0009986cellular_componentcell surface
v0019731biological_processantibacterial humoral response
v0019814cellular_componentimmunoglobulin complex
v0031210molecular_functionphosphatidylcholine binding
v0034987molecular_functionimmunoglobulin receptor binding
v0042834molecular_functionpeptidoglycan binding
v0045087biological_processinnate immune response
v0050829biological_processdefense response to Gram-negative bacterium
v0050853biological_processB cell receptor signaling pathway
v0070062cellular_componentextracellular exosome
v0071753cellular_componentIgM immunoglobulin complex
v0071756cellular_componentpentameric IgM immunoglobulin complex
v0071757cellular_componenthexameric IgM immunoglobulin complex
v0072562cellular_componentblood microparticle
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR194-HIS200
CPHE318-HIS324
CPHE424-HIS430
CTYR534-HIS540
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues898
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues81
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues192
DetailsDomain: {"description":"Ig-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues200
DetailsDomain: {"description":"Ig-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues180
DetailsDomain: {"description":"Ig-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues202
DetailsDomain: {"description":"Ig-like 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues208
DetailsRegion: {"description":"CH1"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues222
DetailsRegion: {"description":"CH2"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues210
DetailsRegion: {"description":"CH3"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues256
DetailsRegion: {"description":"CH4"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16422668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AGJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35981043","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XQ8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"35981043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4742735","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XQ8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35981043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4742735","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XQ8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues32
DetailsRegion: {"description":"Important for IgM oligomerization","evidences":[{"source":"PubMed","id":"32029689","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000219","evidences":[{"source":"PubMed","id":"32029689","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4742735","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KXS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues194
DetailsDomain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues110
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues83
DetailsDomain: {"description":"Ig-like C2-type"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"35981043","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XQ8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

255615

PDB entries from 2026-06-24

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