7XJI
Solabegron-activated dog beta3 adrenergic receptor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 380 | 44255.7 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
3 | N | Nanobody-35 | polymer | 137 | 15015.7 | 1 | unidentified | ||
4 | R | Beta-3 adrenergic receptor | polymer | 395 | 42441.3 | 1 | UniProt (O02662) Pfam (PF00001) In PDB | Canis lupus familiaris (dog) | Beta-3 adrenoreceptor,Beta-3 adrenoceptor |
5 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7547.7 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (cattle) | G gamma-I |
6 | R | 3-[3-[2-[[(2~{S})-2-(3-chlorophenyl)-2-oxidanyl-ethyl]amino]ethylamino]phenyl]benzoic acid | non-polymer | 410.9 | 1 | Chemie (EI5) |
Sequence modifications
A: 5 - 384 (UniProt: P63092)
B: 2 - 340 (UniProt: P54311)
R: 2 - 379 (UniProt: O02662)
G: 1 - 67 (UniProt: P63212)
PDB | External Database | Details |
---|---|---|
Asp 49 | Gly 49 | engineered mutation |
Asn 50 | Glu 50 | engineered mutation |
Tyr 63 | Leu 63 | engineered mutation |
Asp 249 | Ala 249 | engineered mutation |
Asp 252 | Ser 252 | engineered mutation |
- | Asn 254 | deletion |
- | Met 255 | deletion |
- | Val 256 | deletion |
- | Ile 257 | deletion |
- | Arg 258 | deletion |
- | Glu 259 | deletion |
- | Asp 260 | deletion |
- | Asn 261 | deletion |
- | Gln 262 | deletion |
- | Thr 263 | deletion |
Ala 362 | Ile 372 | engineered mutation |
Ile 365 | Val 375 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp -8 | - | expression tag |
Tyr -7 | - | expression tag |
Lys -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Ala -1 | - | expression tag |
Met 0 | - | expression tag |
Gly 1 | - | expression tag |
Glu 380 | - | expression tag |
Asn 381 | - | expression tag |
Leu 382 | - | expression tag |
Tyr 383 | - | expression tag |
Phe 384 | - | expression tag |
Gln 385 | - | expression tag |
Gly 386 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 68 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 148004.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 410.9 | |
All* | Total formula weight | 148415.6 |