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7XJI

Solabegron-activated dog beta3 adrenergic receptor

Functional Information from GO Data
ChainGOidnamespacecontents
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0003091biological_processrenal water homeostasis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007190biological_processactivation of adenylate cyclase activity
A0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
A0007608biological_processsensory perception of smell
A0010856molecular_functionadenylate cyclase activator activity
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031748molecular_functionD1 dopamine receptor binding
A0032588cellular_componenttrans-Golgi network membrane
A0046872molecular_functionmetal ion binding
A0046907biological_processintracellular transport
A0048589biological_processdevelopmental growth
A0050796biological_processregulation of insulin secretion
A0050890biological_processcognition
A0060348biological_processbone development
A0060789biological_processhair follicle placode formation
A0070062cellular_componentextracellular exosome
A0070527biological_processplatelet aggregation
A0071377biological_processcellular response to glucagon stimulus
A0071380biological_processcellular response to prostaglandin E stimulus
A0071870biological_processcellular response to catecholamine stimulus
A0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0001750cellular_componentphotoreceptor outer segment
B0001917cellular_componentphotoreceptor inner segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008283biological_processcell population proliferation
B0010659biological_processcardiac muscle cell apoptotic process
B0030159molecular_functionsignaling receptor complex adaptor activity
B0030425cellular_componentdendrite
B0030507molecular_functionspectrin binding
B0042622cellular_componentphotoreceptor outer segment membrane
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0071456biological_processcellular response to hypoxia
G0003924molecular_functionGTPase activity
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0002025biological_processnorepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
R0004930molecular_functionG protein-coupled receptor activity
R0004935molecular_functionadrenergic receptor activity
R0004939molecular_functionbeta-adrenergic receptor activity
R0004993molecular_functionG protein-coupled serotonin receptor activity
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
R0007268biological_processchemical synaptic transmission
R0015052molecular_functionbeta3-adrenergic receptor activity
R0016020cellular_componentmembrane
R0030425cellular_componentdendrite
R0030594molecular_functionneurotransmitter receptor activity
R0042803molecular_functionprotein homodimerization activity
R0043235cellular_componentreceptor complex
R0043410biological_processpositive regulation of MAPK cascade
R0045202cellular_componentsynapse
R0051378molecular_functionserotonin binding
R0051379molecular_functionepinephrine binding
R0051380molecular_functionnorepinephrine binding
R0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCALAVDRYLaV
ChainResidueDetails
RALA123-VAL139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7626050
ChainResidueDetails
GALA2
ASER54
ALEU197
ATHR204
AASP223
ALEU292
APHE366

site_idSWS_FT_FI2
Number of Residues95
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
RARG64-THR72
RASP134-ARG155
RARG226-ARG292

site_idSWS_FT_FI3
Number of Residues18
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250
ChainResidueDetails
RASN73-VAL91

site_idSWS_FT_FI4
Number of Residues54
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
RPRO92-GLU111
RARG179-PRO203
RARG315-PRO326

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250
ChainResidueDetails
RLEU112-VAL133

site_idSWS_FT_FI6
Number of Residues22
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250
ChainResidueDetails
RALA156-TRP178

site_idSWS_FT_FI7
Number of Residues21
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250
ChainResidueDetails
RTYR204-ALA225

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250
ChainResidueDetails
RTHR293-MET314

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250
ChainResidueDetails
RALA327-CYS347

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
RCYS361

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN8
RASN26

219140

PDB entries from 2024-05-01

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