7X3P
Crystal structure of human SIRT5 in complex with diazirine inhibitor 9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | polymer | 277 | 30183.3 | 1 | UniProt (Q9NXA8) Pfam (PF02146) | Homo sapiens (human) | Regulatory protein SIR2 homolog 5,SIR2-like protein 5 |
| 2 | B (A) | 5-[[(5~{S})-6-[[(1~{S})-1-(4-hydroxyphenyl)-2-oxidanylidene-2-(prop-2-ynylamino)ethyl]amino]-6-oxidanylidene-5-[[4-[3-(trifluoromethyl)-1,2-diazirin-3-yl]phenyl]carbonylamino]hexyl]amino]-5-sulfanylidene-pentanoic acid | non-polymer | 674.7 | 1 | Chemie (8VG) | |||
| 3 | C (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | water | water | 18.0 | 391 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30183.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 846.2 | |
| All* | Total formula weight | 31029.5 |
