7X3P

Crystal structure of human SIRT5 in complex with diazirine inhibitor 9

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0036054	molecular_function	protein-malonyllysine demalonylase activity
A	0036055	molecular_function	protein-succinyllysine desuccinylase activity
A	0070403	molecular_function	NAD+ binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22076378","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29180469","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	27
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22076378","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22767592","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2006","submissionDatabase":"PDB data bank","title":"Crystal structure of human sirtuin homolog 5 in complex with NAD.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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