7X1O
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with double inhibitors HF and L95
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bifunctional glutamate/proline--tRNA ligase | polymer | 505 | 57530.8 | 2 | UniProt (P07814) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) In PDB | Homo sapiens (human) | Bifunctional aminoacyl-tRNA synthetase,Cell proliferation-inducing gene 32 protein,Glutamatyl-prolyl-tRNA synthetase |
| 2 | A, B | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one | non-polymer | 414.7 | 2 | Chemie (HFG) | |||
| 3 | A, B | ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide | non-polymer | 374.4 | 2 | Chemie (JE6) | |||
| 4 | A, B | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 5 | A, B | BROMIDE ION | non-polymer | 79.9 | 2 | Chemie (BR) | |||
| 6 | A, B | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 7 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 115061.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2317.5 | |
| All* | Total formula weight | 117379.2 |
