7X1O
Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with double inhibitors HF and L95
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004827 | molecular_function | proline-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006433 | biological_process | prolyl-tRNA aminoacylation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24100331, ECO:0007744|PDB:4K87 |
| Chain | Residue | Details |
| A | THR1121 | |
| A | ARG1152 | |
| A | HIS1242 | |
| B | THR1121 | |
| B | ARG1152 | |
| B | HIS1242 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K87, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S |
| Chain | Residue | Details |
| A | GLU1154 | |
| B | THR1276 | |
| A | ARG1163 | |
| A | THR1164 | |
| A | THR1240 | |
| A | THR1276 | |
| B | GLU1154 | |
| B | ARG1163 | |
| B | THR1164 | |
| B | THR1240 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37212275, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S |
| Chain | Residue | Details |
| A | GLN1237 | |
| A | ARG1278 | |
| B | GLN1237 | |
| B | ARG1278 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K86, ECO:0007744|PDB:4K87, ECO:0007744|PDB:5V58, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S |
| Chain | Residue | Details |
| A | CYS1448 | |
| B | CYS1448 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K86, ECO:0007744|PDB:4K87, ECO:0007744|PDB:4K88, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S |
| Chain | Residue | Details |
| A | CYS1453 | |
| A | CYS1497 | |
| B | CYS1453 | |
| B | CYS1497 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K86, ECO:0007744|PDB:4K87, ECO:0007744|PDB:4K88, ECO:0007744|PDB:5V58, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S |
| Chain | Residue | Details |
| A | CYS1495 | |
| B | CYS1495 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| A | ARG1152 | |
| B | ARG1152 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1350 | |
| B | SER1350 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS1503 | |
| B | LYS1503 |
