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7WIY

Cryo-EM structure of human TPH2 tetramer

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(B, C, D, A)
Tryptophan 5-hydroxylase 2polymer49056129.64UniProt (Q8IWU9)
Pfam (PF00351)
Homo sapiens (human)Neuronal tryptophan hydroxylase,Tryptophan 5-monooxygenase 2
2E, G, I, K
(B, C, D, A)
FE (III) IONnon-polymer55.84Chemie (FE)
3F, H, J, L
(B, C, D, A)
IMIDAZOLEnon-polymer69.14Chemie (IMD)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight224518.4
Non-Polymers*Number of molecules8
Total formula weight499.7
All*Total formula weight225018.2
*Water molecules are not included.

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PDB entries from 2026-01-21

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